Felipe Tapia

Tectono-stratigraphic evolution of the Andean Orogen between 31 and 37°S (Chile and Western Argentina)

Abstract In this classic segment, many tectonic processes, like flat-subduction, terrane accretion and steepening of the subduction, among others, provide a robust framework for their understanding. Five orogenic cycles, with variations in location and type of magmatism, tectonic regimes and development of different accretionary prisms, show a complex evolution. Accretion of a continental terrane in the Pampean cycle exhumed lower to middle crust in Early Cambrian. The Ordovician magmatic arc, associated metamorphism and foreland basin formation characterized the Famatinian cycle. In Late Devonian, the collision of Chilenia and associated high-pressure/low-temperature metamorphism contrasts with the late Palaeozoic accretionary prisms. Contractional deformation in Early to Middle Permian was followed by extension and rhyolitic (Choiyoi) magmatism. Triassic to earliest Jurassic rifting was followed by subduction and extension, dominated by Pacific marine ingressions, during Jurassic and Early Cretaceous. The Late Cretaceous was characterized by uplift and exhumation of the Andean Cordillera. An Atlantic ingression occurred in latest Cretaceous. Cenozoic contraction and uplift pulses alternate with Oligocene extension. Late Cenozoic subduction was characterized by the Pampean flat-subduction, the clockwise block tectonic rotations in the normal subduction segments and the magmatism in Payenia. These processes provide evidence that the Andean tectonic model is far from a straightforward geological evolution.

FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation

Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription factor forkhead box O1 (FoxO1) regulates many cell functions, including cell death by apoptosis, proliferation, and differentiation. However, several aspects of this process remain unclear, including the role of FoxO1 in cardiac fibroblast differentiation and the regulation of FoxO1 by TGF-β1. Here, we report that TGF-β1 stimulates FoxO1 expression, promoting its dephosphorylation, nuclear localization and transcriptional activity in cultured cardiac fibroblasts. TGF-β1 also increases differentiation markers such as α-smooth muscle actin, connective tissue growth factor, and pro-collagen I, whereas it decreases cardiac fibroblast proliferation triggered by fetal bovine serum. TGF-β1 also increases levels of p21waf/cip-cycle inhibiting factor protein, a cytostatic factor promoting cell cycle arrest and cardiac fibroblast differentiation. In addition, TGF-β1 increases cardiac fibroblast contractile capacity as assessed by collagen gel contraction assay. The effect of TGF-β1 on cardiac fibroblast differentiation was prevented by FoxO1 down-regulation and enhanced by FoxO1 overexpression. Thus, our findings reveal that FoxO1 is regulated by TGF-β1 and plays a critical role in cardiac fibroblast differentiation. We propose that FoxO1 is an attractive new target for anti-fibrotic therapy.

Aprendiendo de la informalidad. Participación comunitaria y enfoque situado como marco para la reconstrucción

Taking into consideration two characteristics, which can be found in informal models: the standpoint theory and the community participation, this research suggests a theoretical reflection on how urban design strategies can be re-thought within natural disaster contexts. The following approach understands reconstruction as a socio-spatial process. This means that rebuilding cannot be focus exclusively on physical rehabilitation. Actually, the action of rebuilding should promote permanent links and bonds between community and the inhabited place. This particular reading is based on the capacity of the urban design process to open up an affective field. Acting within emergency contexts implies then, to widen the traditional project programme. According to this, architectural or urban project will be defined as a relational system, organized by the requirements found on the ground itself. The dual reality emergency-opportunity –which can be associated both to natural disaster scenarios and informality– enables a field where this conceptual approach to urban design based on social demands can be practiced.