Felix Wróblewski

TRANSAMINASE ACTIVITY IN HUMAN BLOOD

Enzymatic transamination consists of the enzyme catalyzed reversible transfer of the alpha amino nitrogen of an amino acid to an alpha-keto acid with the synthesis of a second amino acid and a second alpha-keto acid. Enzymes catalyzing different transamination reactions are found widely distributed in animal tissues and have been shown to change in activity in some tissues during disease (1-3). These observations prompted the present study to determine if transaminase activity could be demonstrated in human serum and blood cellular elements and, if so, to study any variations in activity of this enzyme in the blood of normal and diseased man.

SERUM GLUTAMIC OXALACETIC TRANSAMINASE ACTIVITY AS AN INDEX OF LIVER CELL INJURY: A PRELIMINARY REPORT

Excerpt INTRODUCTION Glutamic oxalacetic transaminase is widely distributed in animal tissues. Its greatest concentration, however, is in heart muscle, skeletal muscle, brain, liver and kidney, in ...

Isoenzymes and myocardial infarction.

PLASMA and serum enzyme-activity alterations have proved useful as laboratory parameters in the diagnosis of myocardial disease.1 Among the enzymes employed to reflect myocardial necrosis are aldol...

Serum transaminase levels in experimental myocardial infarction.

Serum glutamic oxalacetic transaminase concentrations rise sharply after myocardial infarction produced by bead embolization of the coronary tree in the closed chest dog. The peak concentration is reached in 9 to 23 hours post injury. Rises 20 to 30 times greater than normal may be obtained and are directly correlated with the amount of infarction estimated at autopsy. Serial serum transaminase levels may provide a clinical tool to supplement the electrocardiogram in the diagnosis of acute myocardial infarction as well as provide a roughly quantitative estimate of the amount of myocardium involved.

SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGP-T) IN HEPATIC DISEASE: A PRELIMINARY REPORT

Excerpt INTRODUCTION Significant and characteristic alterations in the activity of serum glutamic oxaloacetic (SGO-T) have been shown to follow acute heart muscle and liver cell injury and to provi...

THE DIAGNOSTIC, PROGNOSTIC AND EPIDEMIOLOGIC SIGNIFICANCE OF SERUM GLUTAMIC OXALOACETIC TRANSAMINASE (SGO-T) ALTERATIONS IN ACUTE HEPATITIS

Excerpt INTRODUCTION Glutamic oxaloacetic transaminase (GO-T) is widely distributed in animal and human tissues. Its greatest activity has been found in homogenates of heart muscle, skeletal muscle...

The Influence of Rheumatic Fever on Serum Concentrations of the Enzyme, Glutamic Oxalacetic Transaminase

Variations in serum concentration of the enzyme, glutamic oxalacetic transaminase, in 64 patients with rheumatic fever were studied. Elevations were noted in 17 of 26 patients with carditis of definite or questionable activity and transiently in one rheumatic subject with viral myocarditis. Except for one patient with polyarthritis and equivocal evidence of acute cardiac involvement, serum concentrations were normal during noncardiac rheumatic manifestations and inactive carditis. There was no relationship to temperature, sedimentation rate, white blood count or C-reactive protein. Intermittent necrosis of myocardial fibers probably leads to these increased serum transaminase concentrations.

THE CLINICAL SIGNIFICANCE OF LACTIC DEHYDROGENASE ACTIVITY OF SEROUS EFFUSIONS

Excerpt INTRODUCTION Observations from tissue culture studies suggest that malignant neoplastic cells contribute increasing amounts of lactic dehydrogenase (LD) activity to the fluid medium which b...

Increasing clinical significance of alterations in enzymes of body fluids.

Excerpt INTRODUCTION An inestimable wealth of biochemical information dealing with the measurement, characterization and distribution of tissue enzymes has accrued over the years. These archives in...

Supraventricular Tachycardia Complicating Surgical Procedures A Study of the Contributing Causes, Course, and Treatment of this Complication in Fifty Patients

Persistent postoperative supraventricular tachycardia, despite adequate therapy, is a bad prognostic sign, and cardiac failure due to, or associated with, arrhythmia responds poorly to treatment. Of the 12 patients (24 per cent) resistent to therapy, eight developed congestive heart failure, with five dying as a result. The preoperative, intraoperative and postoperative factors contributing to the causes of this complication are reviewed, and the therapy, course and end results are discussed.