Fermín Fernández-Calderón

Impulsivity and executive functions in polysubstance-using rave attenders

ObjectivesRave parties are characterized by high levels of drug use and polysubstance-using patterns that may be especially harmful for psychological and neuropsychological functioning. The aim of this study was to conduct a comprehensive assessment of different aspects of impulsivity and executive functions in a sample of polysubstance-using rave attenders.MethodsWe collected data from two groups: rave attenders (RvA, n = 25) and drug-free healthy comparison individuals (HCI, n = 27). RvA were regular users of cannabis, cocaine, methampethamine, hallucinogens, and alcohol. The assessment protocol included a drug-taking interview, the UPPS-P Impulsive Behavior Scale, the delay-discounting questionnaire and a set of neuropsychological tests taxing different aspects of executive functions: response speed, working memory, reasoning, response inhibition and switching, self-regulation, decision making, and emotion perception.ResultsFor impulsivity measures, RvA had significantly elevated scores on lack of perseverance and positive and negative urgency, but did not differ from controls on lack of premeditation or sensation seeking. For neuropsychological functioning, RvA had significantly poorer performance on indices of analogical reasoning, processing speed, working memory, inhibition/switching errors, and decision making, but performed similar to controls on indices of self-regulation, reversal learning, and emotion processing. Peak and binge alcohol and drug use were positively correlated with positive urgency, and negatively correlated with performance on executive indices.ConclusionRave attenders have selective alterations of impulsive personality and executive functions. These findings can contribute to delineate the neuropsychological profiles that distinguish recreational polysubstance use from substance dependence.

Self-regulation and treatment retention in cocaine dependent individuals: A longitudinal study

BACKGROUND We aimed to explore the association between baseline executive functioning and treatment outcome in Therapeutic Communities (TCs). METHODS We used a longitudinal descriptive design: a baseline neuropsychological assessment was performed within the first 30 days of treatment in TCs. Once participants finished or abandoned treatment, the information about time of stay in treatment was computed for each individual. The study was conducted across six TCs located in the region of Andalusia (Spain): Cartaya, Almonte, Mijas, Los Palacios, La Línea, and Tarifa. Participants were 131 patients with cocaine dependence who initiated and finished treatment in TCs between January 2009 and December 2010 (2 years). Cognitive assessment was composed of general measures of executive functioning: Letter Number Sequencing (working memory) and Similarities (reasoning), and executive tasks sensitive to ventromedial prefrontal cortex dysfunction, including the Delis-Kaplan Stroop test (inhibition/cognitive switching), the Revised-Strategy Application Test (strategy application/multitasking), and the Iowa Gambling Task (decision-making). The outcome measure was retention, defined as time in TC treatment (number of days). RESULTS Poor executive functioning significantly predicted shorter treatment retention in cocaine dependent individuals on TC residential treatment (14% of explained variance). Reduced performance on the R-SAT, a multitasking test taxing the ability to develop and apply the best strategy to organize multiple sub-routine tasks in order to achieve a long-term goal, was the most powerful predictor of treatment retention. CONCLUSIONS Self-regulation deficits predict the capacity to remain in residential treatment among cocaine dependents.

Polysubstance Use Patterns in Underground Rave Attenders: A Cluster Analysis.

Drug use in mainstream rave parties has been widely documented in a large number of studies. However, not much is known about drug use in underground raves. The purpose of this study is to find out the polysubstance use patterns at underground raves. Two hundred and fifty-two young people between the ages of 18 and 30 who went to underground raves were interviewed. They were given a questionnaire to collect information on drug use at raves. Ravers used a mean of 4.9 different drugs at the last rave they had been to. Over 75% of them used tobacco, alcohol, cannabis, and amphetamine, and over half also used powder ecstasy. Two differentiated use patterns were found: one pattern concentrated more on the use of stimulants and the other on the use of hallucinogens. Underground ravers have a “standard” sociodemographic profile. The use of drugs is much higher than equivalent age group. Higher drug use prevalence than in mainstream rave parties is also observed. Different patterns of use appear which will be necessary to consider in designing preventions and risk reduction strategies.

Harm Reduction Behaviors Among Young Polysubstance Users at Raves

BACKGROUND Raves may be considered recreational settings in which drug use and health risks related to polydrug use are higher than in others. Harm reduction behaviors implemented by ravers are of particular relevance in reducing such risks. This study analyzes harm reduction behaviors and their relationship to raver polysubstance use patterns. METHODS Cross-sectional study of 248 ravers recruited at underground raves in Andalusia (Spain). A questionnaire was developed to collect information about their sociodemographics, drug use, and harm reduction behaviors. RESULTS The results show that ravers employ harm reduction behaviors for minimizing drug-related harm. Nevertheless, only a small minority of the participants frequently employed harm reduction behavior for polysubstance use as well. Ravers identified as high polysubstance users protected themselves significantly less than those identified as low polysubstance users. CONCLUSIONS This study provides empirical information that may be useful for harm reduction intervention in a hidden and hard-to-reach population like rave attendees. The results point to the need to inform and increase harm reduction behavior specifically aimed at polysubstance use by ravers, especially among more frequent users. Future directions for research are also suggested.

Reliability and Validity of the Spanish Version of the Substance Dependence Severity Scale

Purpose: The purpose of this study was to estimate the reliability and provide evidence for the validity of the Spanish version of the Substance Dependence Severity Scale (SDSS). Methods: A total of 211 substance abusers recruited at a public center that provides treatment for substance-related disorders in an outpatient setting were assessed. Reliability was estimated by Cronbachs α and test-retest. Validity evidence was studied by analyzing the relationships with the European Addiction Severity Index (EuropASI) and Health-Related Quality of Life for Drug Abusers (HRQoLDA). Results: Adequate reliability coefficients were found for the dependence scales of all addressed substances (α = 0.737 to 0.877; test-retest r = 0.796-0.952). Low internal consistency was found for the abuse scales (α = 0.329-0.694), and adequate test-retest coefficients on alcohol, cocaine and heroin (test-retest r = 0.708-0.902). The reliability of the cannabis abuse scales was inadequate. The SDSS scores showed significant relationships with the EuropASI and HRQoLDA dimensions. Conclusions: The psychometric analyses validate the use of the severity of dependence scales. The SDSS abuse scales must be used taking the limitations detected into consideration.

Adaptación al español de la Substance Dependence Severity Scale: resultados preliminares

The Substance Dependence Severity Scale -SDSS- is one of the few scales that assesses substance dependence and abuse according DSM criteria in dimensional terms. Several studies have provided evidence of psychometric validity and reliability in its English version, but there is no Spanish version available. The aim of this work was to describe the adaptation process of the English version of the SDSS into Spanish, and provide preliminary results on its reliability and validity evidence. Participants were 146 patients (79.6% male), consumers of alcohol, cocaine, heroin and cannabis admitted to treatment in the Drug Abuse Centre Services of Huelva. Besides the SDSS, the EUROPASI and the Health Related Quality of Life for Drug Abusers test -HRQOLDA- were also administered. The Substance Dependence Severity Scale -SDSS- has shown adequate psychometric properties in terms of the rates of discrimination and internal consistency (α=0.881 for alcohol; α=0.814 for cocaine; α=0.531 for cannabis; α=0.785 for heroin). However, the scale assessing abuse showed poorer results. Concerning the validity evidence, the evidence based on internal structure showed a unidimensional structure. Furthermore, the evidence based from the relationships with other variables empirically support the theoretical relationships postulated. Preliminary results support the use of the Substance Dependence Severity Scale. The severity scale, which evaluates abuse criteria, needs further empirical evidence to assess its utility. Therefore, its current version is not recommended for use.

Personality Inventory for DSM-5–Short Form (PID-5-SF): Reliability, Factorial Structure, and Relationship With Functional Impairment in Dual Diagnosis Patients:

Section III of the Diagnostic and Statistical Manual of Mental Disorders–Fifth edition (DSM-5) has generated a personality paradigm consisting of 25 personality facets identified in five domains. The developed assessment instrument Personality Inventory for DSM-5 (PID-5) has showed good psychometric properties, but the potential for certain improvements still remain. In this article, a sample of 282 dual diagnosis patients is used to provide evidence of the psychometric properties of the PID-5–Short Form. The mean value of Cronbach’s alpha coefficients reached .73 on the facets and .84 for domains and test–retest values ranged between .57 to .83 for facets and .70 to .87 for the domains. Confirmatory factor analyses conducted showed good fit on both models tested: the five correlated factor structure and hierarchical structure of personality traits. The WHODAS 2.0 domains of understanding and communicating, and participating in society, appear to show the strongest relationship with personality facets. In general, the PID-5–Short Form shows adequate psychometric properties for use in dual diagnosis patients.

Reliability, convergent and structural validity and cut-off score of the Severity of Dependence Scale for recreational ketamine users.

BACKGROUND AND AIMS There is a lack of instruments for measuring ketamine substance use disorders. The aims were (i) to estimate the reliability and provide evidence of validity of the Severity of Dependence Scale (SDS) in a sample of recreational users, and (ii) propose a cut-off point to determine the presence of dependence. METHODS We conducted a web-based cross-sectional survey with recreational users who accessed webs related to recreational drug use and harm reduction. 264 recreational ketamine users who had taken it in the past month participated in the study. The Spanish version of the SDS was used. Information on ketamine use-related problems and ketamine use patterns was also collected. RESULTS The reliability estimation calculated by the Cronbachs alpha coefficient was 0.776. SDS showed evidence of convergent validity based on relationships with other variables. Two comparisons were made in this study to analyze the Receiver Operating Characteristic Curve. For frequency of use in the last month the area under curve (AUC) was 0.835 (CI=0.775-0.895) with optimal discrimination at an SDS score of 3. For having been in treatment for decreasing or quitting ketamine use the AUC was 0.902 (CI=0.840-0.963) and the cut-off point was 4. Confirmatory factor analysis showed a one-dimensional structure when Items 3 and 4 were correlated. CONCLUSIONS This study has provided evidence of reliability and validity of the ketamine version of the SDS for recreational users. Considering that ketamine use is linked to young people and its strong potential for causing serious impairment, a cut-off of 3 is proposed as indicative of dependence.

Psychometric Properties and Adaptation of the ASRS in a Spanish Sample of Patients With Substance Use Disorders: Application of Two IRT Rasch Models

The Adult ADHD Self-Report Scale (ASRS; Kessler et al., 2005) is one of the most extensively used scales to detect attention-deficit hyperactivity disorder (ADHD) in adults. The aim of this work is to analyze the psychometric properties of the 18 ASRS items in people with substance use disorders (SUDs). Furthermore, we aimed to (a) confirm or, if necessary, modify the dichotomization criteria of the items proposed by the authors, and (b) identify the most informative items for a screening version or, when applicable, confirm the use of the 6 items that comprise the initially proposed short version. The ASRS was completed for 170 patients with SUD at the Provincial Unit for Drug Dependence of Huelva, Spain, aged 16 to 78 years. Two Rasch models—the dichotomous Rasch model and the Rating Scale Model (RSM) for polytomous items—were used in the psychometric analysis. The ASRS items fitted the RSM adequately, but the locations of the items along the underlying construct led us to propose new criteria of dichotomization. After analyzing the information function of dichotomized items, we identified 6 items that should integrate a new screening scale. Our dichotomization proposal is different from the original one and takes into account the different weights of the items. The selected screening version showed better metric properties than the other analyzed versions. Future research should test our proposal by using external criteria and to obtain evidences for other populations, cultures, or patient profiles.

Adult ADHD Self-Report Scale: Comprehensive Psychometric Study in a Spanish SUD Sample.

Objective: The purpose of this study is to provide reliability and validity evidence of the Adult Self-Report Scale (ASRS) scores on different versions and scoring procedures in a Spanish substance use disorder (SUD) sample. Method: The sample was made up of 170 outpatients diagnosed with SUD. The ASRS, the Mini-International Neuropsychiatric Interview (MINI), and the Substance Dependence Severity Scale were administered. Results: The results of the confirmatory factor analysis (CFA) showed adequate fit to the structure proposed by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) in the 18-item version. On the screening scale, best fit was found for a model with two correlated factors (inattention and hyperactivity). The exploratory factor analysis (EFA) showed that the ADHD items converge and are differentiated from symptoms of withdrawal. The regression analyses showed that severity of dependence is explained by the ASRS scores. Conclusion: Both versions of the ASRS showed adequate psychometric properties. The polytomous or dichotomous score is relevant in patient classification.