Fernanda Mombrini Pigatti

Immunohistochemical expression of Bcl-2 and Ki-67 in oral lichen planus and leukoplakia with different degrees of dysplasia

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown cause. Malignant transformation in OLP lesions may be favored by changes in the expression of proteins that regulate cell proliferation and apoptosis. This study aimed to investigate these issues by immunohistochemical staining for Bcl‐2 and Ki‐67 and by correlating histopathological findings in samples from lesions of OLP and leukoplakia with epithelial dysplasia.

Carcinoma ex pleomorphic adenoma of the palate composed of invasive micropapillary salivary duct carcinoma and adenoid cystic carcinoma components: an unusual case with immunohistochemical approach.

AbstractCarcinoma ex pleomorphic adenoma (CXPA) is an unusual epithelial malignancy that develops from a primary or recurrent pleomorphic adenoma (PA), the most common tumor of salivary glands, and constitutes about 11.5% of all carcinomas that affect these glands. Intraoral minor salivary glands and seromucous glands of the oropharynx are uncommon locations of CXPA. On histopathological examination, the tumor comprises a wide morphological spectrum with a variable proportion between the benign and malignant components with the latter often predominating and overlapping the PA, which may cause misdiagnosis. Here, we report a case of palatal minor salivary gland CXPA composed of invasive micropapillary salivary duct carcinoma and adenoid cystic carcinoma components with multiple nodal metastases in a 74-year-old woman. Neoplastic cells showed heterogeneous immunohistochemical profile with both luminal and myoepithelial differentiation. The invasive micropapillary salivary duct carcinoma component demonstrated overexpression of the oncoprotein human epidermal growth factor receptor-2. This feature should be considered and evaluated as a possible target for adjuvant therapy in case of metastatic disease.

Rosai-Dorfman Disease With Widespread Oral-Maxillofacial Manifestations: A Case Report

a c s t e t t Rosai-Dorfman disease (RDD), first described in 1969, also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon, benign histiocytic disorder of unknown etiology. It predominantly affects children and adolescents through involvement of the cervical lymph nodes, presenting a massive bilateral lymphadenopathy, the characteristic aspect most described in the literature. Fever, leukocytois, and high erythrocyte sedimentation rates have een reported. Although the presenting symptoms are comparable to an infection, its etiology remains unknown. A link to immunologic disorders has een suggested, yet there has been no confirmation of specific mechanism to support this claim. Extranodal manifestations of the disease occur in up to 43% of patients, with 75% presenting manifestations

Doing more with less: the challenging diagnosis of polymorphous low-grade adenocarcinoma in incisional biopsy samples.

The diagnosis of polymorphous low‐grade adenocarcinoma (PLGA) remains difficult for general pathologists, particularly in cases of small biopsy samples. We aimed to characterize the histopathological spectrum and immunohistochemical aspects by using an accessible immunohistochemical panel of cytoskeletal proteins in limited samples of PLGA.