Fernanda Oliveira Camargo Herreros

Remodeling of the human dermis after application of salicylate silanol

Recently, a controlled double-blind study in patients with photo-aged facial skin demonstrated the beneficial role of oral intake of silanol for skin, hair and nails. The aim of our pilot study was to investigate histologic alterations in human skin after injection of silanol. Seven healthy female caucasian volunteers with a moderate degree of photoaged skin received ten sessions of weekly injections of 0.1% salicylate silanol in the left ventral lateral forearm. The histologic features of punch biopsies of the treated area and the nontreated contralateral arm were compared and the collagen and elastic fibers quantified. Texture analysis was performed on digitalized microscopic images by analyzing the Sarkar fractal dimension or amplitudes (inertia values) after Fast Fourier transformation. The treated area revealed a statistically significant increase of the density of both collagen and elastic fibers. Texture analysis showed more compact and homogenously distributed collagen fibers after silicon injection. Our results suggest that the application of silicon may stimulate the production of collagen and elastic fibers leading to remodeling of the dermal fiber architecture, which may explain the improvement of the skin surface observed in clinical studies.

Mesotherapy: a bibliographical review

Intradermotherapy is a medical procedure introduced by Pistor in 1958 that consists in the application of intradermal injections of diluted pharmacological substances that are given directly into the region to be treated. There are reports of the use of intradermotherapy to treat painful diseases, skin diseases and unaesthetic conditions. Medical clinics have been recently offering the treatment of intradermotherapy, using the more popular name for this practice - mesotherapy. There is only scant scientific information about this subject published in periodicals indexed on MedLine. Only a few states rigorously pursue this method. Most indexed publications about this subject deal with the complications of this technique. Unaesthetic dermatoses have been a common complaint in dermatologic clinics, and it has become necessary to have scientific evidence to give to patients. Therefore, well-researched scientific studies about this technique are necessary to offer data to medical professionals that will clearly explain to patients both the benefits and the risks of these procedures. A bibliographical review was conducted and we verified the need for new studies with adequate methods to confirm the benefits of intradermotherapy as used in dermatologic treatment.A intradermoterapia e um procedimento medico introduzido por Pistor, em 1958, e consiste na aplicacao, diretamente na regiao a ser tratada, de injecoes intradermicas de substâncias farmacologicas muito diluidas. Esse metodo e capaz de estimular o tecido que recebe os medicamentos tanto pela acao da punctura quanto pela acao dos farmacos, e apregoa-se que sua vantagem e evitar o uso de medicacao sistemica. Ha relatos da utilizacao da intradermoterapia para tratamento de doencas dolorosas, dermatoses e condicoes consideradas inesteticas. Atualmente, clinicas medicas oferecem esse tratamento, utilizando, porem, o nome mais popular para essa pratica, mesoterapia. Ha escassa informacao cientifica sobre o tema publicada em periodicos indexados no MedLine e poucos estudos com metodologia mais rigorosa sobre a eficacia e o mecanismo de acao da via intradermica. A maioria das publicacoes indexadas sobre esse tema versa sobre as complicacoes dessa tecnica. As dermatoses inesteticas tem se tornado queixas frequentes nos consultorios dermatologicos, sendo necessario um embasamento cientifico para lidar com tais pacientes, os quais, muitas vezes, estao em busca das novidades mostradas atraves da midia. Assim, ha necessidade de estudos cientificamente bem conduzidos sobre essa tecnica. Estes estudos deverao oferecer aos medicos elementos para esclarecer os pacientes sobre quais beneficios esperar e quais os riscos de tal abordagem. Desse modo, realizou-se uma revisao bibliografica sobre o assunto e constatou-se a necessidade de novos estudos com metodologia adequada para a confirmacao dos beneficios da intradermoterapia como ferramenta util no tratamento dermatologico.

Mesoterapia: uma revisão bibliográfica

Intradermotherapy is a medical procedure introduced by Pistor in 1958 that consists in the application of intradermal injections of diluted pharmacological substances that are given directly into the region to be treated. There are reports of the use of intradermotherapy to treat painful diseases, skin diseases and unaesthetic conditions. Medical clinics have been recently offering the treatment of intradermotherapy, using the more popular name for this practice - mesotherapy. There is only scant scientific information about this subject published in periodicals indexed on MedLine. Only a few states rigorously pursue this method. Most indexed publications about this subject deal with the complications of this technique. Unaesthetic dermatoses have been a common complaint in dermatologic clinics, and it has become necessary to have scientific evidence to give to patients. Therefore, well-researched scientific studies about this technique are necessary to offer data to medical professionals that will clearly explain to patients both the benefits and the risks of these procedures. A bibliographical review was conducted and we verified the need for new studies with adequate methods to confirm the benefits of intradermotherapy as used in dermatologic treatment.A intradermoterapia e um procedimento medico introduzido por Pistor, em 1958, e consiste na aplicacao, diretamente na regiao a ser tratada, de injecoes intradermicas de substâncias farmacologicas muito diluidas. Esse metodo e capaz de estimular o tecido que recebe os medicamentos tanto pela acao da punctura quanto pela acao dos farmacos, e apregoa-se que sua vantagem e evitar o uso de medicacao sistemica. Ha relatos da utilizacao da intradermoterapia para tratamento de doencas dolorosas, dermatoses e condicoes consideradas inesteticas. Atualmente, clinicas medicas oferecem esse tratamento, utilizando, porem, o nome mais popular para essa pratica, mesoterapia. Ha escassa informacao cientifica sobre o tema publicada em periodicos indexados no MedLine e poucos estudos com metodologia mais rigorosa sobre a eficacia e o mecanismo de acao da via intradermica. A maioria das publicacoes indexadas sobre esse tema versa sobre as complicacoes dessa tecnica. As dermatoses inesteticas tem se tornado queixas frequentes nos consultorios dermatologicos, sendo necessario um embasamento cientifico para lidar com tais pacientes, os quais, muitas vezes, estao em busca das novidades mostradas atraves da midia. Assim, ha necessidade de estudos cientificamente bem conduzidos sobre essa tecnica. Estes estudos deverao oferecer aos medicos elementos para esclarecer os pacientes sobre quais beneficios esperar e quais os riscos de tal abordagem. Desse modo, realizou-se uma revisao bibliografica sobre o assunto e constatou-se a necessidade de novos estudos com metodologia adequada para a confirmacao dos beneficios da intradermoterapia como ferramenta util no tratamento dermatologico.

Cryosurgical treatment of lentigo maligna.

Background: Lentigo maligna (LM) is a common melanocytic malignancy which requires therapy because of the risk of progression to invasive lentigo maligna melanoma which a much worse prognosis.

Cutaneous Atypical Mycobacteriosis After Ultrasound Hydrolipoclasia Treatment

Case ReportUltrasound hydrolipoclasia is a form of mesotherapy in which physiological solution is injected subdermally before ultrasound application; it is an off-label treatment for localized fatty areas. A 28-year-old white woman presented with painful erythematous-secreting nodules in her abdomen