Fernando R. Pinacho Crisóstomo

Stereoselective synthesis of syn-2,7-disubstituted-4,5-oxepenes

Abstract An efficient synthesis of the title compounds as pure enantiomers is reported. The method is based on the intramolecular trapping of a carbocation generated by acid treatment of exo -Co 2 (CO) 6 -propargyl alcohols by a stereochemically controlled secondary hydroxy group located in a suitable chain.

Sustainable oxidations with air mediated by gallic acid: potential applicability in the reutilization of grape pomace

Gallic acid converts atmospheric oxygen into hydrogen peroxide, which is able to oxidize arylboronic acids as a proof of concept of sustainable oxidations. Moreover, tannic acid and grape pomace extract are also able to perform oxidations with air. Therefore this work unleashes an alternative method for reutilization and valorization of bio-wastes rich in tannins.

Synthesis of New Benzocyclotrimer Analogues: New Receptors for Tetramethylammonium Ion Recognition.

Using a [2 + 2 + 2] cycloaddition/Mitsunobu reaction sequence, a convenient synthesis to access new benzocyclotrimer analogues has been developed. The new receptors have the geometry and functionality capable of recognizing the tetramethylammonium ion in the gas phase and in solution.

Asymmetric synthesis of the (2S,4S,6S)-2,4,6-trimethylnonyl subunit of siphonarienes

The paper describes an asymmetric approach to the synthesis of the (2S,4S,6S)-2,4,6-trimethylnonyl segment of siphonarienes. The key step used is a newly developed methodology to obtain sec-dialkyl acetylenes based on theintramolecular hydride transfer from a secondary γ-benzyloxy group with well-defined absolute stereochemistry, ensured by a Sharpless asymmetric epoxidation reaction, to a cation generated by Lewis acid treatment of a tertiary Co 2 (CO) 6 -complexed propargylic alcohol.