esani F

Chemotherapy of carcinoma of the breast with triethylene thiophosphoramide

15 patients affected with advanced mammary carcinoma have been treated with triethylene-thio-phosphoramide (Thio-Tepa). The drug, which has practically no damaging side-effects at the doses employed, allows, in the majority of the cases, considerable improvements; in some patients a regression of the neoplastic lesions (especially lympboglandular and pleuro-pulmonary) has been obtained. Favourable results, especially with regard to the duration, have been obtained by the associatdon of chemotherapy and endocrino-surgical operations. The reasons for the use of Thio-Tepa in 14 patients during the intervention of breast removal and in the days immediately following it, are presented and discussed.15 patients affected with advanced mammary carcinoma have been treated with triethylene-thio-phosphoramide (Thio-Tepa). The drug, which has practically no damaging side-effects at the doses employed, allows, in the majority of the cases, considerable improvements; in some patients a regression of the neoplastic lesions (especially lymphoglandular and pleuro-pulmonary) has been obtained. Favourable results, especially with regard to the duration, have been obtained by the association of chemotherapy and endocrino-surgical operations.The reasons for the use of Thio-Tepa in 14 patients during the intervention of breast removal and in the days immediately following it, are presented and discussed.