Figen Yargucu Zihni

Coexistence of Takayasu's arteritis with familial Mediterranean fever.

Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by recurrent self-limited attacks of fever, accompanied with peritonitis, pleuritis or arthritis. It is well known that FMF may coexist with vasculitic pathologies, especially with those involving small and medium vessels. Among the vasculitic pathologies reported to be associated with FMF, Henoch–Schönlein purpura and polyarteritis nodosa come the first, possibly followed up by protracted febrile myalgia. However, coexistence of FMF with any large vessel vasculitis has not been reported to date. Here, we present a case with FMF who later developed Takayasu arteritis, with a severe disease course, being resistant to corticosteroids and conventional immunosuppressive agents, and requiring infliximab treatment.

Granülomatöz polianjiit; hastalık aktivasyonu mu, enfeksiyon mu?

Granulomatoz polianjiit bircok sistemi tutan, hayati tehdit eden bir hastaliktir. Tedavi stratejileri hastaligi iyilestirdigi gibi enfeksiyonlara yatkinligi da arttirmaktadir. Enfeksiyonlar taninin ilk yilindaki en onemli olum nedenidir. Hastaligin seyrinde gorulebilen enfeksiyonlar hastalik aktivasyonu ile ayirici tanida her zaman dusunulmelidir. Ayirici tanida klinik seyir, laboratuvar tetkikleri, patolojik incelemeler ve radyolojik goruntulemeler yardimci olmaktadir. Granulomatoz polianjiit tanisi ile izledigimiz olgumuzda hastalik aktivasyonu ile karisabilecek enfeksiyonlara dikkat cekmeye calistik.

Stroke presenting with an isolated foot drop in a patient with antiphospholipid syndrome: an uncommon clinical entity

Dear editor, Antiphospholipid syndrome (APS) is a disease characterized by hypercoagulable state and thrombotic events. Cerebrovascular disease is a common manifestation in APS and there are many different presentations of stroke. We herein describe a patient with APS presenting with isolated foot drop associated with stroke, which is commonly attributed to peripheral etiologies like a peroneal nerve lesion.