Filippo Cassano

Effect of lead on the levels of some immunoregulatory cytokines in occupationally exposed workers

Lead (Pb) may affect humoral and cellular immunity, acting on lymphocytes as well as on granulocytes and monocytes. Cytokines and nitric oxide (NO) play a central role in the immune balance. In this study, plasma levels of nitrites and nitrates (NOx), IL2, IL4, IL6, IL10, TNF-α and INF-γ, were measured in healthy workers with very low (Pb-B =3.2 -18.0 μg/dL) and low (Pb-B = 9.1 -46.0 μg/dL) Pb-exposure compared to non-exposed workers. Low Pb-exposed workers (Pb-B =9.1 -46.0 μg/ dL) were found to have significantly higher plasma IL-10 levels, and tendentially higher plasma TNF-α levels compared to non-exposed workers. This is the first report of a significant increase of plasma IL-10 levels in Pb-exposed workers. Plasma IL-10 increase was influenced by blood Pb levels even after correction for main confounding factors. No difference was found in plasma NOx levels between Pb-exposed and non-exposed workers, which is in agreement with previous findings exclusively regarding groups in the general population. Low Pb-exposure can induce an increase of pro-inflammatory cytokines, such as TNF-α, with a consequent increase of other cytokines, such as IL-10, considered a T cell cross-regulatory factor, suggesting possible interference of Pb in the system of immunophlogosis. Human & Experimental Toxicology (2007) 26, 551 - 556