Fillipe V. Rocha

3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity

Complexes of the type [PdX2(tdmPz)] {X=Cl-(1), Br-(2); I-(3); SCN-(4); tdmPz=1-thiocarbamoyl-3,5-dimethylpyrazole} have been synthesized and characterized. Compound 1 was formed from the reaction between [PdCl2(CH3CN)2] and 1-thiocarbamoyl-3,5-dimethylpyrazole. Complexes 2, 3 and 4 were obtained by metathesis of the chloro groups from 1 by bromide, iodide and thiocyanate ions, respectively. All the compounds and cisplatin have been tested in vitro by MTT assay for their cytotoxicity against three murine cancer cell lines: mammary adenocarcinoma (LM3 and LMM3) and lung adenocarcinoma (LP07) as well towards normal murine peritoneal exudate cells (PEC). Promising cytotoxic effect against LM3 has been found for 3 showing IC50 equal to 24.5 microM which is comparable to the value obtained for cisplatin (30.3 microM).

Cationic Pd(II) complexes acting as topoisomerase II inhibitors: Synthesis, characterization, DNA interaction and cytotoxicity.

• Cationic palladium compounds were prepared bearing thiosemicarbazide and triphenylphosphine.

Crystal structure of (E)-2-[4-(4-hy­droxy­phen­yl)butan-2-yl­idene]hydrazine-1-carbo­thio­amide

The title compound, C11H15N3OS, is a thiosemicarbazone derivative of the raspberry ketone rheosmin [systematic name: 4-(4-hydroxyphenyl)butane-2-one]. The molecule deviates from planarity, with the bridging C—C—C=N torsion angle equal to −101.3 (2)°. The maximum deviation from the mean plane of the non-H atoms of the thiosemicarbazone fragment [C=N—N—C(= S)—N] is 0.085 (5) Å for the Schiff base N atom, and the dihedral angle between this mean plane and the aromatic ring is 50.31 (8)°. In the crystal, molecules are linked by N—H⋯O, N—H⋯S and O—H⋯S hydrogen bonds, forming a three-dimensional structure, with the molecules stacked along [011].

CCDC 1843506: Experimental Crystal Structure Determination

Related Article: Gabriela F. Bozza, Renan L. de Farias, Ronan F.F. de Souza, Fillipe V. Rocha, Carolina V. Barra, Victor M. Deflon, Eduardo T. de Almeida, Antonio E. Mauro, Adelino V.G. Netto|2019|J.Mol.Struct.|1175|195|doi:10.1016/j.molstruc.2018.07.108

CCDC 1843504: Experimental Crystal Structure Determination

Related Article: Gabriela F. Bozza, Renan L. de Farias, Ronan F.F. de Souza, Fillipe V. Rocha, Carolina V. Barra, Victor M. Deflon, Eduardo T. de Almeida, Antonio E. Mauro, Adelino V.G. Netto|2019|J.Mol.Struct.|1175|195|doi:10.1016/j.molstruc.2018.07.108

CCDC 1843505: Experimental Crystal Structure Determination

Related Article: Gabriela F. Bozza, Renan L. de Farias, Ronan F.F. de Souza, Fillipe V. Rocha, Carolina V. Barra, Victor M. Deflon, Eduardo T. de Almeida, Antonio E. Mauro, Adelino V.G. Netto|2019|J.Mol.Struct.|1175|195|doi:10.1016/j.molstruc.2018.07.108

CCDC 1843503: Experimental Crystal Structure Determination

Related Article: Gabriela F. Bozza, Renan L. de Farias, Ronan F.F. de Souza, Fillipe V. Rocha, Carolina V. Barra, Victor M. Deflon, Eduardo T. de Almeida, Antonio E. Mauro, Adelino V.G. Netto|2019|J.Mol.Struct.|1175|195|doi:10.1016/j.molstruc.2018.07.108

N-Methyl-2-(1-methyl-3-phenyl­prop-2-en-1-yl­idene)hydrazinecarbo­thio­amide

In the title compound, C12H15N3S, the molecule deviates slightly from planarity, with a maximum deviation from the mean plane of the non-H atoms of 0.2756 (6) Å for the S atom and a torsion angle for the N—N—C—N fragment of −7.04 (16)°. In the crystal, molecules are linked by N—H⋯S hydrogen-bond interactions, forming centrosymmetric dimers. Additionally, one weak intramolecular N—H⋯N hydrogen-bond interaction is observed. The crystal packing shows a herringbone arrangement viewed along the c axis.