Fiona Duncan

A mixed-methods study of interprofessional learning of resuscitation skills

Objectives  This study aimed to identify the effects of interprofessional resuscitation skills teaching on medical and nursing students’ attitudes, leadership, team‐working and performance skills.

Fatigue after stroke: a systematic review of associations with impaired physical fitness

Background Fatigue is a common and distressing post stroke symptom. One important hypothesis is that fatigue after stroke may be triggered by physical deconditioning, which sets up a vicious, self-perpetuating cycle of fatigue, avoidance of physical activity, further deconditioning, and more fatigue. If an association between physical activity and fatigue after stroke could be established, this would provide a rationale for developing a physical activity-based treatment. Aims Systematically review all observational studies, which have measured both fatigue poststroke and one or more measures of physical fitness and/or physical activity at the same time-point and reported the association between fatigue and fitness variables. Method Publications were identified by systematically searching databases MEDLINE, EMBASE, CINAHL, PsychInfo, and Sportdiscus using keywords ‘fatigue’, ‘stroke’, ‘fitness’, or ‘activity’ and their associated terms or synonyms. Publications that provided data on associations between fatigue in stroke patients and levels of physical activity, cardiorespiratory fitness and/or muscle strength and mass were included. Results Twenty-nine potential studies were retrieved after scrutinizing the titles and abstracts, of which only three fulfilled our inclusion criteria. No association between fatigue and any measures of physical activity or fitness were found. One study did find, through structural equation modeling techniques that fatigue indirectly influences exercise through self-efficacy expectations. Conclusions There is very limited evidence regarding associations between exercise, fitness, and fatigue after stroke. It still remains highly plausible that exercise can have a positive influence on fatigue. Future research should be longitudinal in design.

Biological correlates of post-stroke fatigue: a systematic review

Kutlubaev MA, Duncan FH, Mead GE. Biological correlates of post‐stroke fatigue: a systematic review. 
Acta Neurol Scand: 2012: 125: 219–227. 
© 2011 John Wiley & Sons A/S.

Exploratory Longitudinal Cohort Study of Associations of Fatigue After Stroke

Background and Purpose— The pathogenesis of poststroke fatigue is unclear. In this prospective study, we explored whether reduced physical activity might contribute to poststroke fatigue or be a consequence of it. Methods— Patients with a recent acute stroke were assessed at 1, 6, and 12 months with, Fatigue Assessment Scale (FAS), a fatigue case definition, Hospital Anxiety and Depression Score, sleepiness, quality of life, and accelerometry (ActivPAL). Bivariate analyses determined associations between fatigue and step count at each time point. Multiple linear regression tested whether 1-month step count independently predicted 6- and 12-month FAS. Results— A total of 136 participants (mean age, 72 years; 64% men) attended ≥1 assessment. ActivPAL data were available for 84 (64%), 69 (66%), and 58 (64%) participants at 1, 6, and 12 months, respectively. At 6 and 12 months, a positive fatigue case definition was associated with lower daily step counts (P=0.014 and 0.013, respectively). At 1, 6, and 12 months, higher FAS (more fatigue) was associated with lower step count (P<0.001, 0.01, and 0.007), higher depression (P<0.001), anxiety scores (P<0.001) and sleepiness (P<0.001), and poorer quality of life (P<0.001). Lower daily step count (P<0.002 and 0.006) and greater anxiety (P<0.001 for both) at 1 month independently predicted higher FAS at 6 and 12 months. Conclusions— Lower step counts at 1 month independently predicted greater FAS for ⩽12 months. Physical activity might be a therapeutic target for poststroke fatigue.

CT and Clinical Predictors of Fatigue at One Month after Stroke

Background: Fatigue is a common and distressing consequence of stroke, and the aetiology of post-stroke fatigue (PSF) is poorly understood. It is unclear whether chronic brain changes [cerebral atrophy and white matter lesions (WML)], stroke lesion location or certain clinical features are related to its development. The aim of this study was to identify, in patients with acute stroke, whether features in different brain regions on routine CT imaging or routinely collected clinical features predicted PSF at 1 month. Methods: In total, 107 patients (62% male) with acute ischaemic or haemorrhagic stroke were assessed for fatigue (Fatigue Assessment Scale), anxiety and depression (Hospital Anxiety and Depression Scale) at 1 month. Admission brain CT was rated using a structured scoring system for (i) severity of atrophy and (ii) severity of WML in different regions of the brain, and (iii) site of acute and previous vascular lesions. Results: Cerebral atrophy of mild or greater severity was present in 84 patients (77.5%) and WML of mild or greater severity was present in 54 patients (50.5%) in at least one of the evaluated brain regions. There was no association between PSF and severity of atrophy or WML, or presence of acute or previous vascular lesions. We used the Oxfordshire Community Stroke Project (OCSP) classification to explore the possible influence of lesion location because a minority of the patients (37.4%) had visible acute lesions. Fatigue scores were higher in patients with clinically diagnosed posterior strokes (p = 0.046), in females (p = 0.05) and in those with higher depression and anxiety scores (ρ = 0.52; p < 0.001 and ρ = 0.49; p < 0.001, respectively). Structural CT variables were not significant predictors of fatigue (log FAS) in a linear regression which controlled for age, sex, pre-stroke fatigue, OCSP classification, depression and anxiety. The significant predictors of fatigue were depression (β = 0.30; p = 0.007) and anxiety (β = 0.28; p = 0.013; adjusted R2 = 0.254). Stroke subtype (according to the OCSP classification) was marginally predictive (β = 0.17; p = 0.05) and sex was not statistically significant (β = 0.15; p = 0.08). Conclusions: Features on routine post-stroke CT do not appear to associate with fatigue at 1 month. However, clinically diagnosed posterior strokes as well as female gender, anxiety and depression may be linked with fatigue. Therefore, clinical vigilance rather than CT features should be used to predict fatigue early after stroke. Further research is needed in this area to establish whether biological mechanisms underlie the development of PSF.

Generic health-related quality of life amongst patients employing different voice restoration methods following total laryngectomy

Abstract Three methods of voice restoration—tracheosophageal speech (TEP), oesophageal speech, electrolarynx—are available following total laryngectomy. TEP produces better voice quality compared with other methods and is assumed to result in better quality of life. Little evidence exists to support the relationship between voice quality and quality of life, however. Advertising this study through several leading laryngectomy charities resulted in the completion of 226 questionnaires (TEP = 147; oesophageal speech = 42; electrolarynx = 37) comprising the Short Form 36 (SF-36) quality of life measure and questions examining perceived voice intelligibility. Additionally, 89 questionnaires comprising only the SF-36 were completed by participants who reported having no serious medical problems, to form a healthy control group. Results indicate that improved voice quality does not result in widespread benefits to quality of life. On only a few dimensions were there differences between voice restoration method: electrolarynx and TEP better than oesophageal speech with respect to pain, TEP better than oesophageal speech with respect to role limitation: physical problems. Additionally whilst widespread differences between voice restoration methods did not occur, all three groups had a worse quality of life compared with the healthy control group. Implications of the results for the selection of voice restoration method to maximize quality of life are discussed.

Clinically significant fatigue after stroke: a longitudinal cohort study.

OBJECTIVE Fatigue is often distressing for stroke survivors. The time course of clinically significant fatigue in the first year after stroke is uncertain. We aimed to determine the frequency, severity and time course of clinically significant fatigue in the first 12 months after stroke onset. METHODS We recruited patients with a recent acute stroke. At about one month, six months and 12 months, we performed a structured interview to identify clinically significant fatigue (case definition), and assessed fatigue severity (Fatigue Assessment Scale (FAS)). RESULTS Of 157 patients who initially consented, 136 attended at least one assessment. At one month, 43/132 (33%) had clinically significant fatigue. Eighty-six attended all three assessments, of whom clinically significant fatigue was present in 24 (28%) at one month, 20 (23%) at six months and 18 (21%) at 12 months; their median (IQR) FAS scores were 23 (18 to 29), 21 (17 to 25) and 22.5 (17 to 28) at one, six and 12 months respectively. Of 101 patients who attended at least the one and six month assessments, fatigue status did not change in 65 (64%), with 9 (9%) fatigued throughout and 56 (55%) non-fatigued throughout; 15 (15%) became non-fatigued, 9 (9%) became fatigued, and in 12 (12%) fatigue status fluctuated across three assessments. CONCLUSION Clinically significant fatigue affected a third of patients one month after stroke. About two thirds of these patients had become non-fatigued by six months, most of whom remained non-fatigued at 12months. Fatigue persists in a third at 12 months.

Impact of graduate mental health workers upon primary care mental health: a qualitative study.

The role of the primary care graduate mental health worker (GMHW) was developed to improve the availability of mental health services within primary care. However, little is known concerning the impact of the role upon primary care mental health. Semistructured interviews were undertaken with 27 key stakeholders (12 clients, 10 managers/supervisors, 5 general practitioners) who had experience of the GMHW role and activities provided. Thematic analysis of interview transcripts highlighted four main themes: Access to primary care mental health, Inappropriate referrals, GMHW characteristics, and Role developments. All participant groups highlighted a range of ways in which the GMHW role was making significant contributions to primary care mental health. Many of these were associated with increasing access to mental health services afforded by the range of interventions provided. Benefits, however, may exclude working clients who expressed concerns about a lack of flexibility in the appointment times offered. Concerns arise as a consequence of inappropriate referrals made by some general practitioners. Such referrals were, in part, motivated by a belief that developments in primary care mental health should have been directed towards clients with more severe difficulties. In conclusion, this study suggests that the GMHW role is having a significant impact upon primary care mental health. Attempts to improve primary care mental health through the incorporation of the GMHW role within stepped care models of mental health service delivery should be encouraged.

Conducting Sensitive Research With Disabled Women Who Experience Domestic Abuse During Pregnancy: Lessons From a Qualitative Study

This research-methods case study shares some practical and methodological reflections on doing sensitive research with participants who are typically underrepresented. We focus specifically on the challenges researchers facing during recruitment and data collection. We reflect on the opportunities and challenges created by engaging with gatekeepers to access “hard to reach groups,” particularly within the context of sensitive research. We also offer practical examples and solutions to help ensure that research interviews are conducted in an accessible and inclusive way. These challenges and solutions are illustrated by examples from a recently completed research project on how domestic abuse affects disabled women’s access to maternity care. Disabled women (women with a long-term health condition or impairment) are at significantly higher risk of experiencing domestic abuse (physical, emotional, sexual, or financial abuse from an intimate partner) than nondisabled women. Pregnancy is a particularly vulnerable period for all women experiencing domestic abuse, but internationally, very few studies have explored how domestic abuse affects disabled mothers. Both disability and domestic abuse are associated with late or poor access to maternity services, and the aim of our study was to understand the particular barriers and facilitators to accessing care when disability and domestic abuse coexist. The study took place during 2012-2014 and involved three phases: a systematic review, interviews with women, and focus groups with maternity care practitioners. The learning from our study is relevant and useful to anyone planning and doing sensitive research with underrepresented populations.