Fiona E. Laine-Pearson

Why chaotic mixing of particles is inevitable in the deep lung.

Fine/ultrafine particles can easily reach the pulmonary acinus, where gas is exchanged, but they need to mix with alveolar residual air to land on the septal surface. Classical fluid mechanics theory excludes flow-induced mixing mechanisms because of the low Reynolds number nature of the acinar flow. For more than a decade, we have been challenging this classical view, proposing the idea that chaotic mixing is a potent mechanism in determining the transport of inhaled particles in the pulmonary acinus. We have demonstrated this in numerical simulations, experimental studies in both physical models and in animals, and mathematical modeling. However, the mathematical theory that describes chaotic mixing in small airways and alveoli is highly complex; it not readily accessible by non-mathematicians. The purpose of this paper is to make the basic mechanisms that operate in acinar chaotic mixing more accessible, by translating the key mathematical ideas into physics-oriented language. The key to understanding chaotic mixing is to identify two types of frequency in the system, each of which is induced by a different mechanism. The way in which their interplay creates chaos is explained with instructive illustrations but without any equations. We also explain why self-similarity occurs in the alveolar system and was indeed observed as a fractal pattern deep in rat lungs (Proc. Natl. Acad. Sci. USA. 99:10173-10178, 2002).

NONLINEAR COUNTERPROPAGATING WAVES, MULTISYMPLECTIC GEOMETRY, AND THE INSTABILITY OF STANDING WAVES*

Standing waves are a fundamental class of solutions of nonlinear wave equations with a spatial reflection symmetry, and they routinely arise in optical and oceanographic applications. At the linear level they are composed of two synchronized counterpropagating periodic traveling waves. At the nonlinear level, they can be defined abstractly by their symmetry properties. In this paper, general aspects of the modulational instability of standing waves are considered. This problem has difficulties that do not arise in the modulational instability of traveling waves. Here we propose a new geometric formulation for the linear stability problem, based on embedding the standing wave in a four-parameter family of nonlinear counterpropagating waves. Multisymplectic geometry is shown to encode the stability properties in an essential way. At the weakly nonlinear level we obtain the surprising result that standing waves are modulationally unstable only if the component traveling waves are modulation unstable. Systems of nonlinear wave equations will be used for illustration, but general aspects will be presented, applicable to a wide range of Hamiltonian PDEs, including water waves.

The long-wave instability of short-crested waves, via embedding in the oblique two-wave interaction

The motivation for this work is the stability problem for short-crested Stokes waves. A new point of view is proposed, based on the observation that an understanding of the linear stability of short-crested waves (SCWs) is closely associated with an understanding of the stability of the oblique non-resonant interaction between two waves. The proposed approach is to embed the SCWs in a six-parameter family of oblique non-resonant interactions. A variational framework is developed for the existence and stability of this general two-wave interaction. It is argued that the resonant SCW limit makes sense a posteriori, and leads to a new stability theory for both weakly nonlinear and finite-amplitude SCWs. Even in the weakly nonlinear case the results are new: transverse weakly nonlinear long-wave instability is independent of the nonlinear frequency correction for SCWs whereas longitudinal instability is influenced by the SCW frequency correction, and, in parameter regions of physical interest there may be more than one unstable mode. With explicit results, a critique of existing results in the literature can be given, and several errors and misconceptions in previous work are pointed out. The theory is developed in some generality for Hamiltonian PDEs. Water waves and a nonlinear wave equation in two space dimensions are used for illustration of the theory.