Fiona Mcdougall Mcdonald

Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors

Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.

Dihydroquinolines as novel n-NOS inhibitors

Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring.

Cardioprotective Effects of Prostacyclin Analogues

In recent years, a considerable amount of evidence has accumulated suggesting that prostacyclin and prostacyclin analogues show cardioprotective activity in a number of different models of myocardial injury. Cardioprotective effects may be manifest in a variety of ways, including biochemical (e.g. conservation/improved recovery of mitochondrial oxidative function), morphological (preservation of myocyte ultrastructure), functional (enhancement of local or global mechanical performance) and electrical (anti-arrhythmic) protection. This has resulted in a multitude of parameters being used to assess both the extent of myocardial injury and the degree of myocardial protection. Tables 1 and 2 summarise some of the situations in which effects of prostacyclin or prostacyclin analogues have been seen, and interpreted as cardioprotection.