Fiona Murphy Kessabi

Synthesis and fungicidal activity of quinolin-6-yloxyacetamides, a novel class of tubulin polymerization inhibitors

A novel class of experimental fungicides has been discovered, which consists of special quinolin-6-yloxyacetamides. They are highly active against important phytopathogens, such as Phytophthora infestans (potato and tomato late blight), Mycosphaerella graminicola (wheat leaf blotch) and Uncinula necator (grape powdery mildew). Their fungicidal activity is due to their ability to inhibit fungal tubulin polymerization, leading to microtubule destabilization. An efficient synthesis route has been worked out, which allows the diverse substitution of four identified key positions across the molecular scaffold.

Synthesis and anti-oomycete activity of novel quinazolin- and benzothiazol-6-yloxyacetamides: Potent aza-analogs and five-ring analogs of quinoline fungicides

Novel quinazolin- and benzothiazol-6-yloxyacetamides show excellent in vivo activity against the three economically most important Oomycete pathogens Phytophthora infestans, Plasmopara viticola and Pythium ultimum. They are polar analogs of known quinolin-6-yloxyacetamides, which are not active against the soil-borne damping-off disease caused by Pythium ultimum. The Bogert quinazoline synthesis, an almost forgotten heterocyclization technique, proved to be highly useful for the concise construction of required quinazolin-6-ol building blocks.

The Significance of Organosulfur Compounds in Crop Protection: Current Examples from Fungicide Research

GRAPHICAL ABSTRACT Abstract Approximately 30% of todays agrochemicals contain at least one sulfur atom. This review article highlights the most important reasons for the fundamental role of sulfur functions in crop protection, such as the occurrence of sulfur in agrochemical pharmacophores, the application of sulfur-containing natural products as lead compounds, the role of sulfur in procidal action, fine-tuning of physico-chemical properties and patent breaking as well as the advantage of sulfur-containing heterocycles compared to their nonsulfur ring isosteres. Case studies from three different mode of action classes give proof, how state-of-the-art organosulfur chemistry enables the synthesis and influences the structure-activity relationships of fungicidally active compounds in the classes of Succinate dehydrogenase inhibitors, tubulin polymerization inhibitors and Cellulose synthase inhibitors.