Flora Ozkalayci

Tako-tsubo cardiomyopathy may lead to permanent changes in left ventricular geometry: Potential implications in the setting of pre-existing myocardial disease?

Article history: Received 9 September 2015 Accepted 3 October 2015 Available online 9 October 2015 dimensions, volumes and wall thickness, etc. might be encountered in a portion of subjects with TTC despite full convalescence as demonstratedwith normalized systolic functions. Moreover, these potential changes in left ventricular geometry due to the impact of a TTC attack might possibly go undetected in previously healthy subjects, but might be associated with significant clinical and echocardiographic changes in the

The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox

Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease. Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and the osteoprotegerin system has been recognized as more important in the pathogenesis of cardiovascular disease. Besides their roles in the regulation of bone resorption, these molecules have been reported to be associated with the pathophysiology of cardiovascular disease. There are conflicting data regarding the impact of osteoprotegerin, a glycoprotein with a regulatory role in the cardiovascular system. The aim of this review is to discuss the current knowledge and the role of osteoprotegerin in cardiovascular disease.

The Impact of Statin Therapy on Mean Platelet Volume and its Seasonal Variation: is it Clinically Relevant?

The Impact of Statin Therapy on Mean Platelet Volume and its Seasonal Variation: is it Clinically Relevant? Seasonal variation in acute cardiovascular conditions and its potential implications have drawn considerable interest in the recent years. Accordingly, several studies have reported a variety of seasonal peaks in the incidence of acute myocardial infarction (AMI) particularly characterized by a winter predominance.

Relationship between Aortic Valve Calcification and the Development of Coronary Collateral in Patients with Coronary Artery Disease

Introductıon: Recent data suggest that angiogenesis have an important role in valve diseases. Aortic valve calcification considered as active athero-inflammatory disease which is characterized by the accumulation of inflammatory cells and neovascularization of the valves. In the literature,studies that show that some of the mediators involved in the development of aortic valve calcification is also associated with the development of coronary collateral. The aim of this study was to investigate the presence of aortic valve calcification on the development of coronary collateral. Methods: In our study, 44 patient who underwent coronary angiography in our department and at least one major epicardial coronary artery with complete occlusion or stenosis of 90% or higher and have an aortic valve calcification in echocardiography were included. As a control group of 52 patients with aortic valve calcification was elected with the same specifications and coronary anatomy were selected. Collateral classified according to the classification of Rentrop as 0,1,2,3. Results: In aortic valve calcification group, age (72.1 9.2 and 68.6 10.3, p1⁄40.09), LDL (168.4 41.6 and 143.1 43.1, p1⁄40.08), CRP (2.4 1.9 and 1.5 1.4, p1⁄40.02) was found to be higher than the group without aortic valve calcification. Multivessel disease was significantly higher in the group with aortic calcification (p1⁄40.001). Also development of collateral was greater in the group of aortic valve calsification (p1⁄40.001).; When the group of collateral compared with group of without collateral, aortic calsification (p1⁄40.008), and one or more vessels 90% stenosis rates (p1⁄40.04) were found to be more than the group without collateral. In the regression analysis, the presence of aortic calcification (b1⁄40.3, t1⁄43.9, p1⁄40.01), and 1 vessels> 1⁄4 90% stenosis (b1⁄40.5, t1⁄45.6, p1⁄40.001) seen as two independent parameters affecting the development of collateral. Conclusıon: In our study, the presence of aortic valve calcification is associated with the development of coronary collateral. Given athero-inflammatory etiopathogenesis of aortic valve calcification, in this process increased tissue cover inflammatory factors were thought to be induced coronary collateral development.