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Dive into the research topics where Florence Leclercq is active.

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Featured researches published by Florence Leclercq.


Circulation | 1997

Effect of the Direct Nitric Oxide Donors Linsidomine and Molsidomine on Angiographic Restenosis After Coronary Balloon Angioplasty The ACCORD Study

Jean-Marc Lablanche; Gilles Grollier; Jean-René Lusson; Jean-Pierre Bassand; Ge´rard Drobinski; Bernard Bertrand; Salvatore Battaglia; Bernard Desveaux; Yves Juillie`re; Jean-Michel Juliard; J.-P. Metzger; Pierre Coste; Jean-Claude Quiret; Jean-Luc Dubois-Randé; Pierre Dominique Crochet; Jacques Boschat; Patrice Virot; Ge´rard Finet; Hervé Le Breton; B. Livarek; Florence Leclercq; Thierry Be´ard; Thierry Giraud; Euge`ne P. McFadden; Michel E. Bertrand

BACKGROUNDnNitric oxide (NO) donors, in addition to their vasodilator effect, decrease platelet aggregation and inhibit vascular smooth muscle cell proliferation. These actions could have beneficial effects on restenosis after coronary balloon angioplasty.nnnMETHODS AND RESULTSnIn a prospective multicenter, randomized trial, 700 stable coronary patients scheduled for angioplasty received direct NO donors (infusion of linsidomine followed by oral molsidomine) or oral diltiazem. Treatment was started before angioplasty and continued until 12 to 24 hours before follow-up angiography at 6 months. The primary study end point was minimal lumen diameter, assessed by quantitative coronary angiography, 6 months after balloon angioplasty. Clinical variables were well matched in both groups. However, despite intracoronary administration of isosorbide dinitrate, the reference diameter in the NO donor group was significantly greater than in the diltiazem group on the preangioplasty, postangioplasty, and follow-up angiograms. Pretreatment with an NO donor was associated with a modest improvement in the immediate angiographic result compared with pretreatment with diltiazem (minimum luminal diameter, 1.94 versus 1.81 mm; P = .001); this improvement was maintained at the 6-month angiographic follow-up (minimal lumen diameter, 1.54 versus 1.38 mm; P = .007). The extent of late luminal narrowing did not differ significantly between groups (loss index in the NO donor and diltiazam groups, 0.35 +/- 0.78 and 0.46 +/- 0.74, respectively; P = .103). Restenosis, defined as a binary variable (> or = 50% stenosis), occurred less often in the NO donor group (38.0% versus 46.5%; P = .026). Combined major clinical events (death, nonfatal myocardial infarction, and coronary revascularization) were similar in the two groups (32.2% versus 32.4%).nnnCONCLUSIONSnTreatment with linsidomine and molsidomine was associated with a modest improvement in the long-term angiographic result after angioplasty but had no effect on clinical outcome. The improved angiographic result related predominantly to a better immediate procedural result, because late luminal loss did not differ significantly between groups.


Pacing and Clinical Electrophysiology | 1999

Left Ventricular Lead Insertion Using a Modified Transseptal Catheterization Technique: A Totally Endocardial Approach for Permanent Biventricular Pacing in End-Stage Heart Failure

Florence Leclercq; François‐Xavier Hager; Jean-Christophe Macia; Claude‐Jean Mariottini; Jean-Luc Pasquié; Robert Grolleau

This article describes a new technique of LV lead insertion, using transseptal catheterization performed through the right internal jugular vein, to obtain a totally endocardial biventricular chronic pacing in end‐stage heart failure. Three patients with QRS widening (> 180 ms) linked to complete left bundle branch block (n = 2) or right ventricular pacing (n = 1) were included in this preliminary study. Catheterization was performed under fluoroscopy and transesophageal echocardiography guidance. Transseptal catheterization was achieved by puncture of the right internal jugular vein at the base of the neck and by using a Brockenbrough needle, the tip curve of which was more curved than the standard model. A flexible long sheath was advanced in the left atrium through the interatrial septum and then a unipolar electrode was placed easily in the LV. The proximal tip of the LV lead was tunneled from the neck to the subclavian area and connected to the ventricular channel of a dual (n = 1) or simple (n = 2) chamber pacemaker. Efficient acute sensing (V wave amplitude = 13 ± 3 mV) and pacing (acute pacing threshold = 0.7 ± 0.4 V) were obtained in the three patients. Early loss of capture occurred in two patients requiring lead replacement. Functional status dramatically improved in all three patients. At 6‐month follow‐up, biventricular pacing was maintained in all patients (mean threshold 1.4 V) who were free of clinical embolic event with oral anticoagulation therapy. This modified technique of jugular transseptal catheterization appears promising for the development of left heart pacing.


American Journal of Cardiology | 2001

Comparison of direct coronary stenting with and without balloon predilatation in patients with stable angina pectoris

Didier Carrié; Khalife Khalife; Bernard Citron; Karl Izaaz; Martial Hamon; Jean Michel Juiliard; Florence Leclercq; Joelle Fourcade; Janus Lipiecki; Rémi Sabatier; Vincent Boulet; Jean-Pierre Rinaldi; Sami Mourali; Michel Fatouch; Elyes El Mokhtar; Fethi Aboujaoudé; Meyer Elbaz; Robert Grolleau; Pierre Gabriel Steg; Jacques Puel

The purpose of this study was to compare the effects of stent placement with and without balloon predilatation on duration of the procedure, reduction of procedure-related costs, and clinical outcomes. Although preliminary trials of direct coronary stenting have demonstrated promising results, the lack of randomized studies with long-term follow-up has limited the critical evaluation of the role of direct stenting in the treatment of obstructive coronary artery disease. Between January and September 1999, 338 patients were randomly assigned to either direct stent implantation (DS+; 173 patients) or standard stent implantation with balloon predilatation (DS-; 165 patients). Baseline clinical and angiographic characteristics were similar in the 2 groups. Procedural success was achieved in 98.3% of patients assigned to DS+ and 97.5% of patients assigned to DS- (p = NS), with a crossover rate of 13.9%. Compared with DS-, DS+ conferred a dramatic reduction in procedure-related cost (


Pacing and Clinical Electrophysiology | 1997

Chronic left main coronary artery occlusion: a complication of radiofrequency ablation of idiopathic left ventricular tachycardia.

Maxime Pons; Lionel Beck; Florence Leclercq; Marc Ferrière; Bernard Albat; Jean-Marc Davy

956.4 +/-


Pacing and Clinical Electrophysiology | 2007

Long‐Term Follow‐Up of Biventricular Pacing Using a Totally Endocardial Approach in Patients with End‐Stage Cardiac Failure

Jean-Luc Pasquié; F. Massin; Jean-Christophe Macia; R. Gervasoni; Agustín Bortone; Guillaume Cayla; Robert Grolleau; Florence Leclercq

352.2 vs


American Journal of Cardiology | 1997

Myocardial viability assessed by Dobutamine echocardiography in acute myocardial infarction after successful primary coronary angioplasty

Florence Leclercq; Patrick Messner-Pellenc; Christophe Moragues; François Rivalland; Denis Carabasse; Jean-Marc Davy; Robert Grolleau-Raoux

1,164.6 +/-


The Journal of Nuclear Medicine | 2015

SPECT Myocardial Perfusion Reserve in Patients with Multivessel Coronary Disease: Correlation with Angiographic Findings and Invasive Fractional Flow Reserve Measurements

Ben Bouallègue F; François Roubille; Benoit Lattuca; Thien-Tri Cung; Jean-Christophe Macia; Richard Gervasoni; Florence Leclercq; Denis Mariano-Goulart

383.9, p <0.0001) and duration of the procedure (424.2 +/- 412.1 vs 634.5 +/- 390.1 seconds, p < 0.0001). At 6-month follow-up, the incidence of major adverse cardiac events including death, angina pectoris, myocardial infarction, congestive heart failure, repeat angioplasty, or coronary artery bypass graft surgery was 5.3% in DS+ and 11.4% in DS- (p = NS). Multivariate analysis demonstrated that major adverse cardiac events rates were related to stent length of 10 mm (relative risk [RR] 3.25, 95% confidence intervals [CI] 1.36 to 7.78; p = 0.008), stent diameter of 3 mm (RR 2.69, 95% CI 1.03 to 7.06; p = 0.043), and complex lesion type C (RR 2.83, 95% CI 1.02 to 7.85; p = 0.045). Thus, in selected patients, this prospective randomized study shows the feasibility of DS+ with reduction in procedural cost and length, and without an increase in in-hospital clinical events and major adverse cardiac events at 6-month follow-up.


Cerebrovascular Diseases | 2001

Transcranial Doppler Detection of Cerebral Microemboli during Left Heart Catheterization

Florence Leclercq; Saad Kassnasrallah; Jean-Baptiste Cesari; Jean-Marie Blard; Jean-Christophe Macia; Patrick Messner-Pellenc; Claude‐Jean Mariottini; Robert Grolleau-Raoux

We describe in this report the development of chronic left main coronary artery (LMCA) occlusion in a young patient 2 years after an uncomplicated, successful ablation of idiophic left ventricular tachycardia. This complication appears to be a late consequence of trauma to the LMCA during the procedure rather than an acute or subacute embolic event.


Atherosclerosis | 2009

Patterns of statin prescription in acute myocardial infarction: The French registry of Acute ST-elevation or non-ST-elevation Myocardial Infarction (FAST-MI)

Jean Ferrières; Vincent Bataille; Florence Leclercq; Philippe Geslin; Jean-Bernard Ruidavets; Gilles Grollier; Paul Bernard; Jean-Pierre Cambou; Tabassome Simon; Nicolas Danchin

Background: Besides standard left ventricular (LV) stimulation via the coronary sinus, a transseptal approach allows left ventricular endocardial stimulation. We report our long‐term observations with biventricular stimulation, using a strictly endocardial system for patients presenting with severe congestive heart failure.


European heart journal. Acute cardiovascular care | 2016

Kinetics of high-sensitivity cardiac troponin T and I differ in patients with ST-segment elevation myocardial infarction treated by primary coronary intervention

Guillaume Laugaudin; Nils Kuster; Amael Petiton; Florence Leclercq; Richard Gervasoni; Jean-Christophe Macia; Thien-Tri Cung; Anne-Marie Dupuy; Kamila Solecki; Benoit Lattuca; Stéphane Cade; Frédéric Cransac; Jean-Paul Cristol; François Roubille

Dobutamine echocardiography (5 and 10 microg/kg/ min) was performed in 40 patients 4 +/- 1 days after acute myocardial infarction reperfused by primary coronary angioplasty. The left ventricle was divided into 11 segments. Reversible myocardial dysfunction was indicated by a decrease in at least 2 grades in the total segmental score. Follow-up echocardiography was performed 2 months later. Contractile reserve was documented in 18 patients with dobutamine echocardiography (45%). Sensitivity, specificity, positive, and negative predictive value of dobutamine echocardiography in predicting improvement in contractile function at follow-up were 82%, 83%, 78%, and 86%, respectively. Negative predictive value was high in all dyssynergic segments (86%). Positive predictive value was higher in hypokinetic than in akinetic segments (73% vs 21%; p <0.05). Recovery of wall motion at follow-up was statistically associated with higher left ventricular ejection fraction (p <0.04), collateral blood flow before reperfusion (p = 0.007), and dobutamine responsiveness (p = 0.0001), and was more frequently observed in hypokinetic than in akinetic segments (p <0.05). Thus, low-dose dobutamine echocardiography accurately predicts the extent of irreversibly damaged myocardium early after successful direct coronary angioplasty in acute myocardial infarction.

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Guillaume Cayla

University of Montpellier

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Benoit Lattuca

University of Montpellier

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Thien-Tri Cung

University of Montpellier

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Robert Grolleau

University of Montpellier

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Stéphane Cade

University of Montpellier

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