Florence Portier

DYNAMICS UNDERLYING PATIENT-VENTILATOR INTERACTIONS DURING NOCTURNAL NONINVASIVE VENTILATION

Noninvasive ventilation is a common procedure for managing patients having chronic respiratory failure. The success of this ventilatory assistance is often linked with patients tolerance that is known to be related to the quality of the synchronization between patients spontaneous breathing cycles and ventilatory cycles delivered by the ventilator. Thirty-four sleep sessions (more than 5000 ventilatory cycles each) were automatically investigated using a specific algorithm processing airflow and pressure time series. Four groups of patients were defined according to the interplay between asynchrony events and leaks. Different mechanisms that depend on sleep stages were thus evidenced. A Shannon entropy was also proposed as a new sleep fragmentation quantification methodology.