Florence Pouget

Prevalence and factors associated with hidradenitis suppurativa: Results from two case-control studies

BACKGROUND Conflicting opinions have been reported regarding the epidemiology of hidradenitis suppurativa. OBJECTIVE We sought to evaluate the prevalence of hidradenitis suppurativa and to identify associated factors. METHODOLOGY Prevalence was evaluated using a representative sample of the French population (n=10,000). Associated risk factors were assessed using two case-control studies, one population-based with 67 self-reported patients and 200 control subjects, and the other clinic-based with 302 medically assessed patients and 906 control subjects. RESULTS The prevalence was 1% of the French population. Multivariate analyses showed a strong association with current smoking in self-reported (odds ratio=4.16, 95% confidence interval [2.99-8.69]) and in medically assessed (odds ratio=12.55 [8.58-18.38]) populations. Association with body mass index was significant in medically assessed patients (odds ratio=1.12 [1.08-1.15]) for each increase of 1 U of BMI. LIMITATIONS A causal relationship could not be established with such a cross-sectional study. CONCLUSION Hidradenitis suppurativa is a common disease, frequently associated with smoking and being overweight.

Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity

BACKGROUND Factors associated with the severity of hidradenitis suppurativa (HS) are not known. OBJECTIVE We sought to identify factors associated with the severity of HS. METHODOLOGY The severity of disease in a series of 302 consecutive patients with HS was assessed using the Sartorius score. RESULTS Atypical locations were more common in men than in women (47.1% vs 14.8%; P < .001). Men also had more severe disease (median Sartorius score: 20.5 vs 16.5; P = .02). Increased body mass index (P < .001), atypical locations (P = .002), a personal history of severe acne (P = .04), and absence of a family history of HS (P = .06) were associated with an increased Sartorius score. The Sartorius score was highly correlated with the intensity and duration of pain and suppuration (all P values < .001). LIMITATIONS The referral center base of the study may have biased recruitment. CONCLUSION Our data showed a significant association between the severity of HS and several clinical and behavioral factors. Prospective studies are needed to confirm the prognostic role of these factors.

Lymphœdème compliquant une hidradénite suppurée : trois observations

Resume Introduction Nous rapportons les observations de deux femmes et un homme âges de 36 a 52 ans souffrant d’hidradenite suppuree depuis de nombreuses annees, compliquee d’un lymphœdeme sus-pubien. Observations L’aspect clinique etait celui d’une tumefaction en ballon de rugby, retombant en besace sur les organes genitaux dans un cas, a consistance ferme voire dure. Il n’y avait pas d’atteinte ganglionnaire ou de blocage des voies lymphatiques abdominales. Une exerese chirurgicale large des lesions suivie secondairement de greffe a entraine la guerison chez un malade. L’examen de la piece operatoire revelait des lymphangiectasies et de la fibrose. Discussion La survenue de lymphœdeme est due au blocage et/ou a la destruction des voies lymphatiques secondaire a l’inflammation et a la suppuration chronique. Une fois la maladie presente, aucun traitement medical n’est efficace.