Frances D. Cannon

Allotransplantation of lung without immunosuppression after transplantation. I. Staged transplantation of bone marrow and lung

Six of 12 animals are alive 8–22 months after transplantation. Five of these animals and one which died of streptococcal pneumonia after pulmonary function testing demonstrated adequate pulmonary function in the transplant. One living recipient has not been studied. Four animals died of a “wasting syndrome” thought to be related to radiation damage to the pancreas rather than graft-versus-host reaction. One animal was killed with a severe skin eruption of unknown cause.

The influence of DL-A compatibility on the survival of hepatic allografts in unmodified mongrel dogs.

Heterotopic hepatic transplantation was performed in 26 pairs of littermate and non-littermate mongrel dogs selected by serological criteria of DL-A compatibility. No immunosuppression was given. In non-littermates, 11 recipients of DL-A incompatible allografts survived 10-22 days (mean 13.4 days). Mean serum bilirubin rose by the 6th day. Three recipients of DL-A compatible allografts survived 13, 41, and 60 days, (mean 38 days). Mean serum bilirubin rose by the 8th day. In littermates, 5 recipients of DL-A incompatible allografts survived 7-12 days (mean 10.2 days) and mean serum bilirubin rose by the 6th day. Four recipients of DL-A compatible allografts from phenotypically DL-A non-identical donors survived 58, 82, 90 and 128 days (mean 89.5 days). Mean serum bilirubin rose by the 29th day. In contrast, 3 recipients of DL-A phenotypically identical allografts survived 171, 536 and over 636 days respectively, with normal mean serum bilirubin levels. The results confirm the role of the DL-A system in hepatic transplantation in mongrel dogs, and suggest that this dog population may constitute a suitable experimental model parallelling the current situation with regard to HL-A compatibility testing in outbred human subjects. The relatively long survival of DL-A compatible heterotopic hepatic allografts, compared with similar transplants of skin, kidney and heart, also suggests a need for studies of possible alteration in parameters of humoral and cellular reactivity in these recipients.