Francesca Benedini

The discovery of a new organic nitrate: an overview.

Organic nitrates have been in therapeutic use for the treatment of angina pectoris for over a century. During the past decade, the search for new organic nitro esters with reduced side effects and improved oral bioavailability has been greatly intensified. We have discovered a new class of organic nitrates characterized by good oral activity and a coronary vascular selectivity greater than that of glyceryl trinitrate. Full structure-activity relationship studies of this new class of nitroesters are reported. From the screening of these compounds, ITF 296 was chosen for further evaluation.

Synthetic Communication: Synthesis of Optically Pure Analogues of D-Arginine Methyl Ester with Antiarrhythmic Activity

Abstract The synthesis of the methyl esters of optically pure trans and cis 4-guanidinocyclohexylglycine as rigid analogues of D-arginine methyl ester are described.

1H and 13C NMR Study of New Organic Nitrate Esters. II—Benzoic Acid‐Substituted Derivatives

The 1H and 13C NMR of a series of benzoic acid‐substituted nitrate esters were measured and assigned on the basis of substituent chemical shifts, COSY experiments and 13C,1H shift correlated spectra