Francesco Migliavacca

Use of rapid prototyping models in the planning of percutaneous pulmonary valved stent implantation

Abstract Percutaneous replacement of the pulmonary valve is a recently developed inter-ventional technique which involves the implantation of a valved stent in the pulmonary trunk. It relies upon careful consideration of patient anatomy for both stent design and detailed procedure planning. Medical imaging data in the form of two-dimensional scans and three-dimensional interactive graphics offer only limited support for these tasks. The paper reports the results of an experimental investigation on the use of arterial models built by rapid prototyping techniques. An analysis of clinical needs has helped to specify proper requirements for such model properties as cost, strength, accuracy, elastic compliance, and optical transparency. Two different process chains, based on the fused deposition modelling technique and on the vacuum casting of thermoset resins in rubber moulds, have been tested for prototype fabrication. The use of anatomical models has allowed the cardiologists confidence in patient selection, prosthesis fabrication, and final implantation to be significantly improved.

Computational fluid dynamic simulations of cavopulmonary connections with an extracardiac lateral conduit

Complex congenital heart defects due to the absence of a ventricular chamber can often be treated by the Fontan surgical procedure. The objective of this work was to quantify the haemodynamics in the Fontan operation (cavopulmonary connection) with extracardiac lateral conduit. Four different models based on the finite element method were constructed with different lengths of inferior anastomosis (range 18-25 mm) and inclinations of the conduit (33 and 47.5 degrees). Mass conservation and Navier-Stokes equations were solved by means of the FIDAP code, based on the finite element method. The left-to-right pulmonary flow ratio and percentage inferior caval blood to the left lung were the highest with the smallest anastomosis and highest inclination: 1.35 and 83.26%, respectively. Dissipated power percentage was higher with the largest anastomosis than with the smallest (19.4 vs 15.8%). It was concluded that, when performing a total cavopulmonary connection, an extracardiac lateral conduit: (i) diverts more flow to the left lung, and (ii) shows higher energy losses when compared with a connection with intra-atrial tunnel. This study could be useful to evaluate the incidence of pulmonary arteriovenous malformations.

Computational model of the fluid dynamics in systemic-to-pulmonary shunts.

A systemic-to-pulmonary shunt is a connection created between the systemic and pulmonary arterial circulations in order to improve pulmonary perfusion in children with congenital heart diseases. Knowledge of the relationship between pressure and flow in this new, surgically created, cardiovascular district may be helpful in the clinical management of these patients, whose survival is critically dependent on the blood flow distribution between the pulmonary and systemic circulations. In this study a group of three-dimensional computational models of the shunt have been investigated under steady-state and pulsatile conditions by means of a finite element analysis. The model is used to quantify the effects of shunt diameter (D), curvature, angle, and pulsatility on the pressure-flow (DeltaP-Q) relationship of the shunt. Size of the shunt is the main regulator of pressure-flow relationship. Innominate arterial diameter and angles of insertion have less influence. Curvature of the shunt results in lower pressure drops. Inertial effects can be neglected. The following simplified formulae are derived: DeltaP=(0. 097Q+0.521Q(2))/D(4) and DeltaP=(0.096Q+0.393Q(2))/D(4) for the different shunt geometries investigated (straight and curved shunts, respectively).

A Computational Pulsatile Model of the Bidirectional Cavopulmonary Anastomosis: The Influence of Pulmonary Forward Flow

The bidirectional cavopulmonary anastomosis (BCPA or bidirectional Glenn) is an operation to treat congenital heart diseases of the right heart by diverting the systemic venous return from the superior vena cava to both lungs. The main goal is to provide the correct perfusion to both lungs avoiding an excessive increase in systemic venous pressure. One of the factors which can affect the clinical outcome of the surgically reconstructed circulation is the amount of pulsatile blood flow coming from the main pulmonary artery. The purpose of this work is to analyse the influence of this factor on the BCPA hemodynamics. A 3-D finite element model of the BCPA has been developed to reproduce the flow of the surgically reconstructed district. Geometry and hemodynamic data have been taken from angiocardiogram and catheterization reports, respectively. On the basis of the developed 3-D model, four simulations have been performed with increasing pulsatile blood flow rate from the main pulmonary artery. The results show that hemodynamics in the pulmonary arteries are greatly influenced by the amount of flow through the native main pulmonary artery and that the flow from the superior vena cava allows to have a similar distribution of the blood to both lungs, with a little predilection for the left side, in agreement with clinical postoperative data.

Calculating blood flow from Doppler measurements in the systemic-to-pulmonary artery shunt after the Norwood operation: a method based on computational fluid dynamics

Hypoplastic left heart syndrome is currently the most lethal cardiac malformation of the newborn infant. Survival following a Norwood operation depends on the balance between systemic and pulmonary blood flow, which is highly dependent on the fluid dynamics through the interposition shunt between the two circulations. We used computational fluid dynamic (CFD) models to determine the velocity profile in a systemic-to-pulmonary artery shunt and suggested a simplified method of calculating the blood flow in the shunt based on Doppler measurements. CFD models of systemic-to-pulmonary shunts based on the finite element method were studied. The size of the shunt has been varied from 3 to 5 mm. Velocity profiles at proximal and distal positions were evaluated and correlations between maximum and mean spatial velocity were found. Twenty-one Doppler measurements in the proximal and distal part of the shunt were obtained from six patients with hypoplastic left heart syndrome. Combining Doppler velocities and CFD velocity profiles, blood flow rate in the shunt was calculated. Flow rate evaluated from aortic Doppler and oxygen saturation measurements were performed for comparison. Results showed that proximal shunt Doppler velocities were always greater than the correspondent distal ones (ratio equal to 1.15 +/- 0.11). CFD models showed a similar behaviour (ratio equal to 1.21 +/- 0.03). CFD models gave a V(mean)/V(max) ratio of 0. 480 at the proximal junction and of 0.579 at the distal one. The agreement between the flow evaluated in the proximal and distal areas of the shunt was good (0.576 +/- 0.150 vs. 0.610 +/- 0.166 l/min). Comparison of these data with saturation data and aortic Doppler measurements correlate less well (0.593 +/- 0.156 vs. 1.023 +/- 0.493 l/min). A formula easily to quantify shunt flow rate is proposed. This could be used to evaluate the effects of different therapeutic and pharmacological manoeuvres in this unique circulation.

A novel flow chamber for biodegradable alloy assessment in physiologically realistic environments.

In order to better understand the in vivo corrosion of biodegradable alloys, it is necessary to replicate the physiological environment as closely as possible. In this study, a novel flow chamber system is developed that allows the investigation of biodegradable alloy corrosion in a simulated physiological environment. The system is designed to reproduce flow conditions encountered in coronary arteries using a parallel plate setup and to allow the culturing of cells. Computational fluid dynamics and analytical methods are used as part of the design process to ensure that suitable flow conditions are maintained in the test region. The system is used to investigate the corrosion behavior of AZ31 alloy foils of different thickness, in test media with and without proteins and in static and dynamic solutions. It is observed that pulsatile flows, similar to those in the coronary arteries, significantly increase corrosion rates and lead to a different corrosion surface morphologies relative to static immersion tests.

Aortic tissue properties in porcine models: A comparison of ex vivo mechanical test results after simulated aortic arch reconstructions

Surgical interventions on the arterial wall can produce modifications to its tissue characteristics, and the addition of synthetic materials of different types can have implications on hemodynamics and blood vessel wall behavior. This work studies the midterm effects of end-to-end anastomosis (E/E), Gore-tex graft interposition (GGI) and Gore-tex patch graft aortoplasty (GPGA) in aortic arch reconstruction. The study comprised of two groups of healthy Danish sows. The sows in the first group (short term (ST)) weighed about 40 kg, underwent a surgical operation and were sacrificed on the same day. The sows in the second group (midterm (MT)) weighed 5-10 kg, underwent a surgical operation and were then allowed to grow to a weight of about 30-40 kg, before being sacrificed. One sow in each group was scheduled for E/E and one sow for GGI. One sow in ST and two sows in MT received GPGA. The overall average wall thickness was 1.93 mm. Relaxation constant values were significantly higher for ST (5.221 +/- 1.832 sec) than for MT (2.184 +/- 1.216 sec). GPGA showed a greater impact on relaxation than other procedures, enhancing the viscous character. The working-point Youngs modulus (Epw ) was not significantly different in ST and MT. Circumferential samples had different Epw (0.419 +/- 0.77 MPa) from longitudinal samples (0.902 +/- 0.378 MPa). There also appeared to be a significant difference between samples cut longitudinally on the left and the right sides of the wall. The overall average Epw value was 0.6609 +/- 0.3641 MPa.