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Francine Sternfeld

Merck & Co.

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Publication

Featured researches published by Francine Sternfeld.

Bioorganic & Medicinal Chemistry Letters | 1996

The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogues: Potent and selective agonists for 5-HT1D receptors☆

Francine Sternfeld; Raymond Baker; Howard B. Broughton; Alexander Richard Guiblin; Richard Alexander Jelley; Victor Giulio Matassa; Austin John Reeve; Margaret S. Beer; Richard Hargreaves; Sara L. Shepheard; Jeanette Longmore; Zerin Razzaque; Michael I. Graham; Bindi Sohal; Leslie J. Street

Optimisation of a series of 5-(heterocyclyl)tryptamines led to the identification of the symmetrically substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT1D receptor affinity and selectivity. The triazole (8) is the most potent and selective, orally bioavailable, 5-HT1D receptor agonist identified to date, showing an order of magnitude greater potency than the clinical compound sumatriptan with improved subtype selectivity.

Journal of Medicinal Chemistry | 2004

Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers

Francine Sternfeld; Robert W. Carling; Richard Alexander Jelley; Tamara Ladduwahetty; Kevin John Merchant; Kevin William Moore; Austin John Reeve; Leslie J. Street; Desmond O'Connor; Bindi Sohal; John R. Atack; Susan M. Cook; Guy R. Seabrook; Keith A. Wafford; F. David Tattersall; Neil Collinson; Gerard R. Dawson; José L. Castro; Angus Murray Macleod

Journal of Medicinal Chemistry | 1995

Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.

Leslie J. Street; Baker R; Davey Wb; Alexander Richard Guiblin; Richard Alexander Jelley; Austin John Reeve; Routledge H; Francine Sternfeld; and Alan P. Watt; Margaret S. Beer

Journal of Medicinal Chemistry | 2004

Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site

Leslie J. Street; Francine Sternfeld; Richard Alexander Jelley; Austin John Reeve; Robert W. Carling; Kevin William Moore; Ruth M. McKernan; Bindi Sohal; Susan M. Cook; Andrew Pike; Gerard R. Dawson; Frances A. Bromidge; Keith A. Wafford; Guy R. Seabrook; George R. Marshall; Goplan V. Pillai; José L. Castro; and John R. Atack; Angus Murray Macleod

Archive | 1998

SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS

William Robert Carling; Tamara Ladduwahetty; Angus Murray Macleod; Kevin John Merchant; Kevin W. Moore; Francine Sternfeld; Leslie J. Street

Journal of Medicinal Chemistry | 1999

Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.

Francine Sternfeld; Alexander Richard Guiblin; Richard Alexander Jelley; Victor Giulio Matassa; Austin John Reeve; Peter Hunt; Margaret S. Beer; Anne Heald; Bindi Sohal; and Alan P. Watt; Leslie J. Street

Archive | 1997

SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABAAα5 RECEPTOR SUBTYPE

William Robert Carling; Angus Murray Macleod; Ruth M. McKernan; Austin John Reeve; Francine Sternfeld; Leslie J. Street

Archive | 1997

Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists

Jose Luis Castro Pineiro; Caroline Henry; Victor Giulio Matassa; Austin John Reeve; Francine Sternfeld; Leslie J. Street

Archive | 1996

Azetidine, pyrrolidine and piperidine derivatives

Raymond Baker; Sylvie Bourrain; Jose Luis Castro Pineiro; Mark Stuart Chambers; Alexander Richard Guiblin; Sarah Christine Hobbs; Richard Alexander Jelley; Andrew Madin; Victor Giulio Matassa; Austin John Reeve; Michael Geoffrey Neil Russell; Graham A. Showell; Francine Sternfeld; Leslie J. Street; Monique Bodil Van Niel

Journal of Medicinal Chemistry | 1997

Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents

Angus Murray Macleod; Leslie J. Street; Austin John Reeve; Richard Alexander Jelley; Francine Sternfeld; Margaret S. Beer; Alan P. Watt; Denise Rathbone; Victor Giulio Matassa

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Leslie J. Street

University of Cape Town

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Austin John Reeve

Merck

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Richard Alexander Jelley

Merck

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Angus Murray Macleod

Merck

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Victor Giulio Matassa

Merck

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Tamara Ladduwahetty

Merck

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Raymond Baker

Merck

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Jason Matthew Elliott

Merck

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Kevin John Merchant

Merck

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William Robert Carling

Merck

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