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Featured researches published by Francis Brion.


Tetrahedron Letters | 1992

Stereoselective synthesis of a trans-octahydroindole derivative, precursor of trandolapril (RU 44 570), an inhibitor of angiotensin converting enzyme.

Francis Brion; Christian Marie; Philippe Mackiewicz; J.M. Roul; Jean Buendia

Abstract We describe a stereoselective synthesis of the trans-octahydroindole-2-carboxylic acid 2 a key intermediate in the elaboration of Trandolapril (RU 44 570) 1 . The optically active starting material used was obtained by an enzymatic hydrolysis.


Archive | 1995

Preparation of 11-keto steroids

Francis Brion; Jean Buendia; Christian Diolez; Michel Vivat


Archive | 1992

New process for the preparation of hydrocortison and new intermediates of this process

Francis Brion; Jean Buendia; Christian Diolez; Michel Vivat


Archive | 1996

Tricyclic derivatives, their preparation, their use in the preparation of optically active or racemic colchicine, thiocolchicine and analogues or derivatives, and intermediates

Francis Brion; Bernadette Chappert; Christian Diolez; Christian Marie; Alain Mazurie; Michel Middendorp; Didier Pronine; Edmond Toromanoff


Archive | 1993

Process and intermediates

Didier Babin; Neerja Bhatnagar; Francis Brion; Colette Colladant


Archive | 1993

Intermediate steroid compounds

Francis Brion; Jean Buendia; Christian Diolez; Michel Vivat


Archive | 1987

Process for making perhydroindole-2-carbonxylic acid

Francis Brion; Jean Buendia; Christian Marie


Archive | 1994

Process for the preparation of hydrocortisone

Francis Brion; Jean Buendia; Christian Diolez; Michel Vivat


Archive | 1992

New steroid derivatives of pregna-4,9(11),17(20)-trien-3-on, their preparation, their use in the preparation of derivatives of pregna-4,9(11),16-trien-3,20-dione and intermediates therefor

Francis Brion; Jean Buendia; Christian Diolez; Michel Vivat


Archive | 1987

Process for the preparation of octahydroindole derivatives and their intermediates

Francis Brion; Jean Buendia; Christian Marie

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