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Francis Petit

Roussel Uclaf

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Featured researches published by Francis Petit.

Neuropharmacology | 1991

The dopamine D2 agonists RU 24213 and RU 24926 are also kappa-opioid receptor antagonists.

Michel Fortin; Mauricette Degryse; Francis Petit; P.F. Hunt

The di-(phenethyl)-amine derivatives, RU 24213 and RU 24926 are widely used as selective dopamine D2-receptor agonists. Binding studies now show that they also have affinity for the kappa-opioid receptor. Their affinity is not greatly reduced in the presence of NaCl/GTP, suggesting an antagonist action. This is confirmed for RU 24926, the more active of the two, using the field-stimulated rabbit vas-deferens. With respect to the mu-receptor, RU 24926 shows low binding affinity and also an antagonist effect. These results demonstrate kappa- as well as mu-antagonist activity in a novel chemical series. Moreover, since the kappa-receptor may regulate dopamine release, the results of experiments using these compounds as dopamine D2 agonists should be interpreted with caution.

Archive | 1991

N-substituted derivatives of α-mercapto alkylamines, their preparation process and the intermediates obtained, their use as medicaments and the compositions containing them

Fran Cedilla Ois Clemence; Odile Le Martret; Francis Petit

Archive | 1995

Pharmaceutical compositions of antiglucocorticoid compounds for treating or preventing symptoms of spontaneous or narcotic-induced withdrawal

Francis Petit; Daniel Philibert; André Ulmann

Archive | 1997

Analgesic, anti-inflammatory and anti-thrombosis esters of nitrated cycloaliphatic alcohols

Serge Droux; Giuseppe Gigliotti; Pascal Joly; Francis Petit

Archive | 1991

N-substituted derivatives of alpha-mercapto alkylamines, process for their preparation and intermediates obtained, their use as medicaments and compositions containing them

Francois Clemence; Martret Odile Le; Francis Petit

Archive | 1988

Derivatives of N-substituted alpha-mercaptomethyl-benzene-propanamide, process for their preparation, their use as medicines and compositions containing them

Jean-Paul Vevert; Jean-Claude Gasc; Francoise Delevallee; Francis Petit

Archive | 1990

Hydroxyphenethylamine derivative and its salts, method of preparation, medical application and use as specific pharmacological tool

Philippe Cosquer; Francoise Delevallee; Serge Droux; Michel Fortin; Francis Petit

Archive | 1989

New derivatives of 20,21-dinoreburnamenine substituted at 15 by an amine group and their salts, the process for preparing them and the intermediates thus obtained, their use as medicaments and the pharmaceutical compounds containing them

Francois Clemence; Jean-Luc Haesslein; Francis Petit; Mauricette Degryse

Archive | 1997

Esters analgesiques, anti-inflammatoires et anti-thrombotiques d'alcools cycloaliphatiques nitres

Serge Droux; Giuseppe Gigliotti; Pascal Joly; Francis Petit

Archive | 1996

Verwendung von antimineralcorticoidverbindungen gegen das drogenentzugssyndrom Using antimineralcorticoidverbindungen against the drug withdrawal syndrome

Francis Petit; Daniel Philibert; Nick Goeders

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Nick Goeders

Aventis Pharma

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