Francisco Cardona
University of Aveiro
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Publication
Featured researches published by Francisco Cardona.
Chemical Communications | 2011
Cristina Airoldi; Francisco Cardona; Erika Sironi; Laura Colombo; Mario Salmona; Artur M. S. Silva; Francesco Nicotra; Barbara La Ferla
A small library of glyco-fused benzopyran compounds has been synthesised. Their interaction features with Aβ peptides have been characterised by using STD-NMR and trNOESY experiments. The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations.
New Journal of Chemistry | 2014
Samuel Guieu; Francisco Cardona; João Rocha; Artur M. S. Silva
A family of hemisalen fluoroborate complexes has been prepared and characterized. These new fluorophores exhibit an intense blue emission upon irradiation with UV light. Interestingly, the introduction of bulky aromatic substituents enhanced the quantum yield considerably, up to 44%. Upon studying various solvents, it appeared that the effect of the phenyl substituents is more of electron donating nature than of restricting the intramolecular motion of the dyes.
Journal of Carbohydrate Chemistry | 2008
Francisco Cardona; Barbara La Ferla
Glycoconjugates such as glycoproteins, glycolipids, and proteoglycans are key components of the living system and are involved in various recognition processes such as cell adhesion, migration, and signaling, and in many pathological events such as autoimmune disease, bacterial and viral invasion of the host, and tumor-cell motility and progression. Understanding how and why these highly specific interactions come about is a hard task due to the difficulties associated with the “microheterogenity” of natural glycoconjugates. Thus, there is an increasing demand for synthetic glycoconjugates for a better comprehension of these biological processes and to expedite the development of therapeutic agents.
Chemistry: A European Journal | 2018
Samuel Guieu; Francisco Cardona; João Rocha; Artur S.M. Silva
A simple synthesis strategy afforded a family of hydrogen-bonded azines and Schiff-bases. Although in dilute solution these dyes are faint light emitters, all exhibit bright luminescence upon aggregation. Changing the peripheral substituents from electron donating to electron withdrawing allows emission fine-tuning in a range from bluish-green to orange-red. The crystal structures of the materials reveal that the restriction of intramolecular rotations is the main mechanism for the aggregation-induced emission enhancement properties.
Natural Product Reports | 2011
Barbara La Ferla; Cristina Airoldi; Cristiano Zona; Alexandre Orsato; Francisco Cardona; Silvia Merlo; Erika Sironi; Giuseppe D'Orazio; Francesco Nicotra
Dyes and Pigments | 2014
Francisco Cardona; João Rocha; Artur M. S. Silva; Samuel Guieu
European Journal of Organic Chemistry | 2014
Francisco Cardona; Giuseppe D'Orazio; Artur M. S. Silva; Francesco Nicotra; Barbara La Ferla
European Journal of Medicinal Chemistry | 2014
Cristina Airoldi; Spyridon Mourtas; Francisco Cardona; Cristiano Zona; Erika Sironi; Giuseppe D'Orazio; Eleni Markoutsa; Francesco Nicotra; Sophia G. Antimisiaris; Barbara La Ferla
Pure and Applied Chemistry | 2013
Cristina Airoldi; Francisco Cardona; Erika Sironi; Laura Colombo; Mario Salmona; Ilaria Cambianica; F Ornaghi; Giulio Sancini; Francesco Nicotra; Barbara La Ferla
Current Bioactive Compounds | 2011
Cristina Airoldi; Erika Sironi; Barbara La Ferla; Francisco Cardona; Francesco Nicotra