Francisco J. Soto
Medical College of Wisconsin
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Current Opinion in Pulmonary Medicine | 2005
Francisco J. Soto; Nicola A. Hanania
Purpose of review Chronic obstructive pulmonary disease (COPD) is a disease state characterized by airflow limitation that is usually progressive. In addition, an abnormal inflammatory response of the lungs to noxious particles or gases can be seen throughout the airways, parenchyma, and pulmonary vasculature. So far, anti-inflammatory medications (eg, inhaled corticosteroids) have failed to show a major effect on the decline of lung function in COPD patients. Novel anti-inflammatory therapies such as selective phosphodiesterase 4 (PDE4) inhibitors are in clinical development. Their potential role in the management of COPD is described in this review. Recent findings Some of the selective PDE4 inhibitors have demonstrated in vitro and in vivo anti-inflammatory activity on cells commonly linked to airway inflammation in COPD, such as neutrophils. While these agents seem to offer only a modest improvement in lung function compared with other bronchodilators, their anti-inflammatory effects appear to provide some substantial benefits in reducing exacerbations and improving health-related quality of life. Summary Based on the available data, the second generation of selective PDE4 inhibitors will likely provide additional therapeutic options for the management of COPD. These agents may become an important tool in the treatment of this disease, since they target three important components of COPD: airway obstruction, inflammation, and structural changes.
Current Opinion in Pulmonary Medicine | 2003
Francisco J. Soto; Basil Varkey
Chest | 2010
Raymond L. Benza; Himanshu Gupta; Francisco J. Soto; Myung H. Park; Fernando Torres; Noam Frey; Srinivas Murali
Chest | 2005
Francisco J. Soto; Ronald Siegel; David Marks; James Kleczka; Timothy Woods; James P. Maloney; Amina Syed; Amjad Syed; Sonika Gupta; Kenneth W. Presberg
Chest | 2007
Fernando Torres; Himanshu Gupta; Srinivas Murali; Myung H. Park; Francisco J. Soto; Chad McQueen; Raymond L. Benza
Chest | 2006
Francisco J. Soto; Priyank Jain; James Kleczka; Ronald Siegel; Timothy Woods; David Marks; Kenneth W. Presberg
american thoracic society international conference | 2012
Raymond L. Benza; Himanshu Gupta; Srinivas Murali; Myung H. Park; Francisco J. Soto; Fernando Torres
american thoracic society international conference | 2010
Raymond L. Benza; Himanshu Gupta; Francisco J. Soto; Myung H. Park; Fernando Torres; Noam Frey; Srinivas Murali
Chest | 2007
Francisco J. Soto
Chest | 2018
Isaac Biney; Paul Branca; Jf Turner; John Callison; Michael T. McCormack; Francisco J. Soto