Francisco Macedo Paschoal

Methylene blue photodynamic therapy in malignant melanoma decreases expression of proliferating cell nuclear antigen and heparanases

Background. Malignant melanoma (MM) is a very aggressive tumour. Although surgical excision of MM in the early stages has a very good prognosis, it often fails to completely inhibit tumour progression. Methylene blue photodynamic therapy (MB‐PDT) is a technique that induces tissue damage by reactive oxygen species (ROS).

Fundamentos da fotografia digital em Dermatologia

Digital technology has promoted a great popularization of photographic registration in several medical areas. Because of its visual nature, dermatology has incorporated the benefits of this tool in clinical practice and research. This article aims to offer guidance to the dermatologist who is unfamiliar with this technology, providing basic understanding for the best use of digital photography equipment.

Basal cell carcinoma appearing in a facial nevus sebaceous of Jadassohn: dermoscopic features

The nevus sebaceous of Jadassohn usually affects the face or scalp. It tends to evolve in three stages, and the final stage is characterized by the appearance of tumours. We present the case of a facial nevus sebaceous of Jadasshon in which a basal cell carcinoma developed. We also explore the diagnosis of this disease, which was established through dermoscopy, and propose using this technique in the clinical follow-up of this type of hamartoma, thereby allowing the early detection of cancer development.

A study of clinical profiles of vitiligo in different ages: an analysis of 669 outpatients

Vitiligo is a skin disorder characterized by achromic macules (white) on the skin and/or mucous membranes, which affects 0.5–2% of the population. Few publications address a vitiligo epidemiological profile worldwide. In Brazil there are only studies in children.

Nevo melanocítico congênito

O nevo melanocitico congenito esta presente em aproximadamente 1% dos recem nascidos. As lesoes classificadas como pequenas e medias sao relativamente comuns, ao passo que o nevo gigante, maior que 20 cm no maior diâmetro, e uma condicao mais rara cuja a incidencia esta estimada em 1 para cada 20 mil nascimentos. As lesoes melanociticas congenitas pequenas e medias tem um risco de degeneracao maligna baixo, raramente ocorrendo na infância. Por outro lado, estima-se um risco entre 5 a 12 % de um melanoma se desenvolver a partir ou relacionado com um nevo gigante, e de regra, metade dos casos ocorrem antes dos 3 anos de idade. Alem da possibilidade de degeneracao maligna, o acometimento neurologico e as implicacoes psicologicas devido ao aspecto estetico sao dois aspectos importantes relacionados com as lesoes gigantes, influindo tambem na decisao e na abordagem terapeutica.

Argyria mimicking a blue nevis: dermoscopy features

Argyria is a rare disease caused by prolonged skin contact with silver. Localized cases have been described regarding the use of topical medications, and trauma with objects containing this metal such as acupuncture needles and jewelry. Clinically, a macule or a patch, round or oval, appears in the infected area, with a characteristic bluey-gray color. To our knowledge this is the first time that this clinical condition has been described through the use of dermoscopy.

Action of topical mometasone on the pigmented halos of micrografting in patients with vitiligo

BACKGROUND Vitiligo is a prevalent skin pigmentation disorder worldwide. The treatments available still offer limited results to some patients. For patients with clinically stable vitiligo, melanocyte transplantation is an appropriate treatment option, and the technique of autologous punch grafting shows good repigmentation. OBJECTIVE To evaluate the effect of topical mometasone on the halos of repigmentation after autologous punch grafting in patients with clinically stable vitiligo. METHODS Between 2009 and 2010, 11 patients with clinically stable vitiligo (7 generalized, 2 focal and 2 segmental) underwent autologous punch grafting in the achromic patches. According to the clinical type of vitiligo, patients were instructed to use the corticosteroid ointment during 6 months, only on a few grafted lesions. In the first month, the mometasone ointment was used twice a day and after that just once. They were reassessed 1, 3 and 6 months after the procedure. Grafted halos were photographed and recorded using the software fotofinder. After 6 months, all the treated and untreated areas of the repigmentation halos were measured and analyzed comparatively. RESULTS The median area of the repigmentation halos after 6 months of treatment with mometasone was larger (25,96 mm(2)) than the one of the untreated halos (13,86 mm(2)), showing a statistically significant difference (p = 0,026). CONCLUSION In this study, the use of mometasone ointment increased the area of the repigmentation halos after punch grafting. However, this should be further investigated in larger samples in order to validate this positive action in the treatment of stable vitiligo.

Carcinoma verrucoso: uma variante clínico-histopatológica do carcinoma espinocelular

Verrucous carcinoma is a rare and indolent variant of the squamous cell carcinoma described by Ackerman in 1948. The oral cavity is a most common site. Clinically, it presents most often as a slow-growing verrucous lesion. The prognosis is good. Treatment of choice is surgery. Patients require frequent reevaluation because recurrences may occur.

Hypomelanotic melanoma mimicking pigmented Bowen disease

Dermaimage Medical Associates; Cutaneous Oncology epartment, AC Camargo Cancer Center; Dermatology epartment, ABC Medical School; Maria Bussade Medical ssociates; and Pathology Department, Universidade Federal S~ao Paulo. ing sources: None. licts of interest: None declared. Reprint requests: Gisele Gargantini Rezze, MD, PhD, Av. General Furtado do Nascimento, 740 cj24, Sao Paulo, SP, Brazil, CEP 05465-070. E-mail: ggrezze@hotmail.com. J Am Acad Dermatol 2016;74:e11-3. 0190-9622/

Aspectos dermatológicos da acromegalia

36.00 a 2015 by the American Academy of Dermatology, Inc. http://dx.doi.org/10.1016/j.jaad.2015.09.052