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Francois Maria Sommen

Janssen Pharmaceutica

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Featured researches published by Francois Maria Sommen.

ACS Medicinal Chemistry Letters | 2015

Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase

Christopher N. Johnson; Valerio Berdini; Lijs Beke; Pascal Bonnet; Dirk Brehmer; Joseph E. Coyle; Phillip J. Day; Martyn Frederickson; Eddy Jean Edgard Freyne; Ron Gilissen; Christopher Charles Frederick Hamlett; Steven Howard; Lieven Meerpoel; Rachel McMenamin; Sahil Patel; David C. Rees; Andrew Sharff; Francois Maria Sommen; Tongfei Wu; Joannes Theodorus Maria Linders

Fragment-based drug design was successfully applied to maternal embryonic leucine zipper kinase (MELK). A low affinity (160 μM) fragment hit was identified, which bound to the hinge region with an atypical binding mode, and this was optimized using structure-based design into a low-nanomolar and cell-penetrant inhibitor, with a good selectivity profile, suitable for use as a chemical probe for elucidation of MELK biology.

Archive | 2000

Respiratory syncytial virus replication inhibitors

Frans Eduard Janssens; Kathleen Petrus Marie-José Meersman; Francois Maria Sommen; Jérôme Emile Georges Guillemont; Jean Fernand Armand Lacrampe; Koenraad Jozef Lodewijk Marcel Andries

Archive | 2003

Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists

Frans Eduard Janssens; Francois Maria Sommen; Benoit Christian Albert Ghislain De Boeck; Joseph Elisabeth Leenaerts

Drug Development Research | 1986

Synthesis of cisapride, a gastrointestinal stimulant derived from cis-4-amino-3-methoxypiperidine

Georges Henri Paul Van Daele; Marcel Frans Leopold De Bruyn; Francois Maria Sommen; Marcel Janssen; Jan M. Van Nueten; Jan A.J. Schuurkes; C. J. E. Niemegeers; Josée E. Leysen

Archive | 1988

Novel 1-alkyl substituted benzimidazole derivatives

Frans Eduard Janssens; Gaston Stanislas Marcella Diels; Joseh Leo Ghislanus Torremans; Francois Maria Sommen

Archive | 1996

1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives as tachykinin receptor antagonists

Frans Eduard Janssens; Francois Maria Sommen; Dominique Louis Nestor Ghislaine Surleraux; Roosbroeck Yves Emiel Maria Van

Archive | 1989

4-(aroylamino)piperidine-butanimide derivatives

Georges Henri Paul Van Daele; Freddy Francois Vlaeminck; Francois Maria Sommen; Michael Anna Jozef De Cleyn

Archive | 2003

Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists

Frans Eduard Janssens; Francois Maria Sommen; Boeck Benoît Christian Albert Ghislain De; Joseph Elisabeth Leenaerts; Roosbroeck Yves Emiel Maria Van; Gaston Stanislas Marcella Diels

Archive | 1991

Novel 4-piperidinylcarbonyl derivatives

Frans Eduard Janssens; Gaston Stanislas Marcella Diels; Francois Maria Sommen

Archive | 1988

2-(heterocyclylalkyl)imidazopyridines

Frans Eduard Janssens; Francois Maria Sommen; Joseph Leo Ghislanus Torremans; Gaston Stanislas Marcell Diels

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Frans Eduard Janssens

Janssen Pharmaceutica

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Joseph Elisabeth Leenaerts

Janssen Pharmaceutica

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Gaston Stanislas Marcella Diels

Janssen Pharmaceutica

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Jérôme Emile Georges Guillemont

Johnson

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Joseph Leo Ghislanus Torremans

Janssen Pharmaceutica

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Koenraad Jozef Lodewijk Marcel Andries

Janssen Pharmaceutica

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Boeck Benoît Christian Albert Ghislain De

Janssen Pharmaceutica

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Ann Christina Joannes Dierckx

Janssen Pharmaceutica

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Jean-François Bonfanti

Tibotec

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Roosbroeck Yves Emiel Maria Van

Janssen Pharmaceutica

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