Françoise Texier-Boullet

Knoevenagel condensation catalysed by aluminium oxide.

Abstract The Knoevenagel condensation of carbonyl compounds with active methylene compounds was readily carried out with aluminium oxide as catalyst.

Knoevenagel, wittig and wittig-horner reactions in the presence of magnesium oxide or zinc oxide.

Abstract Alkenes are prepared by Wittig, Knoevenagel and Wittig-Horner reactions in solid-liquid systems, with magnesium oxide or zinc oxide as catalyst. When Wittig-Horner reaction is competitive with Knoevenagel reaction, the catalyst can be modified to give a highly selective reaction ; the addition of dimethylsulfoxide on MgO or heiamethylphosphoric triamide on ZnO gives more efficient catalysts for the Wittig-Homer reaction. The addition of a small amount of HgCl 2 , or CdCl 2 , on ZnO gives more efficient catalysts for the Knoevenagel reaction.

Synthesis in dry media coupled with microwave irradiation : Application to the preparation of enaminoketones.

Abstract β-diketones react with a variety of amines and aminoesters over clay K 10 or silica under microwave irradiation in open vessels to give within a few minutes, the corresponding enaminoketones with good yields. According to the reaction conditions acylamines may also result.

An unexpected reactivity of simple heterogeneous mixture of γ-alumina and potassium fluoride : 1-hydroxyalkane phosphonic esters synthesis from non-activated ketones in “dry media”.

Abstract 1-Hydroxyalkane phosphonic esters are readily obtained from non-activated ketones and dialkylphosphites by adsorbing them together on a heterogeneous γ-alumina-potassium fluoride mixture.

Preparation and oxidation of α-nitro alcohols with supported reagents.

Abstract Preparation of 2-nitro alkanols has been achieved by condensation of aldehydes with nitroalkanes in the presence of alumina-supported potassium fluoride. Nitroketones are produced by oxidation of nitroalkanols with montmorillonite - supported chromium trioxide.

Reactions de wittig, wittig-horner et knoevenagel par activation anionique avec l'alumine ou le fluorure de potassium depose sur l'alumine, sans solvant

Abstract Wittig, Wittig-Horner and Knoevenagel reactions are achieved in the presence of alumina or potassium fluoride supported on alumina, without organic solvent. The presence of a small amount of water increases the rate of the Wittig and Wittig-Horner reactions. The reaction of the diethyl cyanomethylphosphonate with an aldehyde in the presence of dry alumina is oriented towards the Knoevenagel reaction.

Simple Access to α, β Unsaturated Ketones by Acid-Catalyzed Solvent-Free Reactions

Abstract Various chalcones and dibenzylidene cycloalkanones were readily prepared in a few minutes with good yields by simply mixing aromatic aldehydes with substituted acetophenones or benzaldehyde with cycloalkanones in the presence of catalytic amounts of p-toluene sulfonic acid under focused microwave irradiation.

Alkali metal fluoride mediated Silyl-Reformatsky reaction in solid-liquid media; activation by microwaves

Abstract Condensation of trimethylsilylacetonitrile or ethyltrimethylsilyacetate with benzaldehyde, in the presence of dried alcali metal fluorides in heterogeneous media under microwaves leads readily to β-trimethylsilyloxynitrile or ester according to a Reformatsky type reaction. The later products could be hydrolyzed and dehydrated on the wet inorganic salt to give the corresponding alkenes.

Reactions en milieu heterogene liquide-solide : Reactions de wittig-horner et addition du phosphite de diethyle sur les composes carbonyles en presence de KF, 2H2O.

Resume Potassium fluoride dihydrate in solid-liquid two phase systems, eventually with phase transfer catalysis, is a moderate base which can be used for Wittig-Horner reaction and synthesis of hydroxyphosphonates.

Synthesis in dry media coupled with microwave irradiation: Application to the preparation of β-aminoesters and β-lactams via silyl ketene acetals and aldimines.

Abstract According to the reaction conditions, silyl ketene acetals react with aldimines to give β-aminoesters (montmorillonite clay K 10 , or para-toluenesulfonic acid) or β-lactams (KF/18 crown-6) in a few minutes under microwave irradiation.