Frank J. Carr | Researchain

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Featured researches published by Frank J. Carr.

The Journal of Infectious Diseases | 1997

A Humanized Antibody against Human Cytomegalovirus (CMV) gpUL75 (gH) for Prophylaxis or Treatment of CMV Infections

Anita Hamilton; Donna M. Manuel; Jane E. Grundy; Andrew J. Turner; Susan I. King; John R. Adair; Patricia White; Frank J. Carr; William J. Harris

A humanized monoclonal antibody that binds to the 86-kDa glycoprotein, gpUL75 (gH), of human cytomegalovirus (CMV) has been developed. The six complementarity determining regions of the heavy and light chains of the mouse antibody HCMV16 were transferred to human antibody framework sequences and combined with human antibody constant regions to produce a complete antibody. The reshaped antibody recognized cells infected with a variety of virus strains and neutralized clinical isolates of CMV as efficiently as laboratory strains in a conventional plaque reduction assay. This antibody provides a potential agent for the prevention or treatment of CMV infections in humans.

Nature Biotechnology | 1991

Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in Vivo

Philip R. Tempest; Patricia Bremner; Martin Lambert; Geraldine Taylor; Julie M. Furze; Frank J. Carr; William J. Harris

Archive | 1993

HUMANIZED ANTIBODIES TO Fc RECEPTORS FOR IMMUNOGLOBULIN G ON HUMAN MONONUCLEAR PHAGOCYTES

Philip R. Tempest; William J. Harris; Frank J. Carr

Blood | 2005

An anti-CD20–IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma

Stephen D. Gillies; Yan Lan; Steven. R. Williams; Frank J. Carr; Stephen J. Forman; Andrew Raubitschek; Kin-Ming Lo

Cancer Research | 2000

Construction, Production, and Characterization of Humanized Anti-Lewis Y Monoclonal Antibody 3S193 for Targeted Immunotherapy of Solid Tumors

Andrew M. Scott; Detlef Geleick; Michael R. Rubira; Kerrie Clarke; Edouard C. Nice; Fiona E. Smyth; Elisabeth Stockert; Elizabeth Carswell Richards; Frank J. Carr; William J. Harris; Kathryn Armour; Jeff Rood; Anna Kypridis; Veronika Kronina; Roger Murphy; F-T. Lee; Zhanqi Liu; Kunio Kitamura; Gerd Ritter; Katrina Laughton; Eric W. Hoffman; Antony W. Burgess; Lloyd J. Old

Archive | 1998

Identification of mhc binding peptides

John E. Fothergill; Graham J. L. Kemp; Tony Brooks; Frank J. Carr

Journal of Interferon and Cytokine Research | 2004

The Development of a Modified Human IFN-α2b Linked to the Fc Portion of Human IgG1 as a Novel Potential Therapeutic for the Treatment of Hepatitis C Virus Infection

Tim Jones; Marian Hanlon; Beverley J. Smith; Charles T. Heise; Prakash D. Nayee; Deborah A. Sanders; Anita Hamilton; Clive Sweet; Esther Unitt; Graeme J. M. Alexander; Kin-Ming Lo; Stephen D. Gillies; Frank J. Carr; Matthew Baker

Archive | 2001