Frank Kayser
Merck & Co.
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Publication
Featured researches published by Frank Kayser.
Bioorganic & Medicinal Chemistry Letters | 2003
Shouwu Miao; Jianming Bao; Maria L. Garcia; Joung L. Goulet; Xingfang J. Hong; Gregory J. Kaczorowski; Frank Kayser; Gloria C. Koo; Andrew Kotliar; William A. Schmalhofer; Kashmira Shah; Peter J. Sinclair; Robert S. Slaughter; Marty S. Springer; Mary Jo Staruch; Nancy N. Tsou; Frederick Wong; William H. Parsons; Kathleen M. Rupprecht
The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of immune responses in vivo. A class of benzamide Kv1.3 channel inhibitors has been identified. The structure-activity relationship within this class of compounds in two functional assays, Rb_Kv and T-cell proliferation, is presented. In in vitro assays, trans isomers display moderate selectivity for binding to Kv1.3 over other Kv1.x channels present in human brain.
Cellular Immunology | 1999
Gloria C. Koo; Joseph T. Blake; Kashmira Shah; Mary Jo Staruch; Francis J. Dumont; Denise Wunderler; Manuel Sanchez; Owen B. McManus; Anna Sirotina-Meisher; Paul Fischer; Robert C. Boltz; Michael A. Goetz; Robert K. Baker; Jianming Bao; Frank Kayser; Kathleen M. Rupprecht; William H. Parsons; Xinchun Tong; Ida Ita; Jim Pivnichny; Stella H. Vincent; Paul K. Cunningham; Don Hora; William P. Feeney; Gregory J. Kaczorowski; Martin S. Springer
Biochemistry | 1999
John P. Felix; Randal M. Bugianesi; William A. Schmalhofer; Robert P. Borris; Michael A. Goetz; Otto D. Hensens; Jianming Bao; Frank Kayser; William H. Parsons; Kathleen M. Rupprecht; Maria L. Garcia; Gregory J. Kaczorowski; Robert S. Slaughter
Archive | 1996
Robert K. Baker; Frank Kayser; Jianming Bao; William H. Parsons; Kathleen M. Rupprecht
Archive | 1999
Robert K. Baker; Jianming Bao; Jennifer Chee; Maria L. Garcia; Gregory J. Kaczorowski; Frank Kayser; Andrew Kotliar; Chou Juitsai Liu; Shouwu Miao; William H. Parsons; Kathleen M. Rupprecht; William A. Schmalhofer; Christopher F. Claiborne; David A. Claremon; Nigel Liverton; Wayne J. Thompson
Archive | 2000
Jianming Bao; Christopher Forbes; Frank Kayser; Shouwu Miao; William H. Parsons; Kathleen M. Rupprecht
Archive | 1999
Jianming Bao; Andrew Kotliar; Frank Kayser; William H. Parsons; Kathleen M. Rupprecht; Christopher F. Claiborne; David A. Claremon; Nigel Liverton; Wayne J. Thompson
Archive | 1999
Robert K. Baker; Jianming Bao; Frank Kayser; Andrew Kotliar; William H. Parsons; Kathleen M. Rupprecht; Christopher F. Claiborne; David A. Claremon; Nigel Liverton; Wayne J. Thompson
Archive | 1999
Jianming Bao; Frank Kayser; Robert K. Baker; Shouwu Miao; William H. Parsons; Kathleen M. Rupprecht
Bioorganic & Medicinal Chemistry Letters | 2005
Jianming Bao; Shouwu Miao; Frank Kayser; Andrew Kotliar; Robert K. Baker; George A. Doss; John P. Felix; Randal M. Bugianesi; Robert S. Slaughter; Gregory J. Kaczorowski; Maria L. Garcia; Sookhee Ha; Laurie Castonguay; Gloria C. Koo; Kashmira Shah; Marty S. Springer; Mary Jo Staruch; William H. Parsons; Kathleen M. Rupprecht
