Frank Vanmiddlesworth

The zaragozic acids: Structure elucidation of a new class of squalene synthase inhibitors

Structures of two novel fungal metabolites, zaragozic acids A (1) and B (2), characterized by a novel 2,8-dioxobicyclo[3.2.1] octane-4,6,7-trihydroxy-3,4,5-tricar☐ylic acid core, are proposed predominantly on the basis of 2D NMR.

Structure elucidation of restricticin, a novel antifungal agent from penicillium restrictum

Abstract The structures and absolute stereochemistry of restricticin (1), its N,N-dimethyl derivative (4) and desglycyl hydrolysis product (3), isolated from Penicillium restrictum, have been determined on the basis of spectroscopic evidence. They belong to a new class of broad spectrum antifungal agents representing substituted tetrahydropyranyl ethers incorporating triene and glycyl ester side chains.

Structure elucidation of L-687,781, a new β-1,3-D-glucan synthesis inhibitor.

Abstract A new β-1,3 glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. Through NMR, mass spectroscopy, and degradation studies the structure of L-687,781 was determined to be 1 , a novel member of the papulacandin family of antifungal agents. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.