Franklin R. Nuzum

The Urinary Output of Catechol Derivatives Including Adrenaline in Normal Individuals, in Essential Hypertension, and in Myocardial Infarction

Based on Shaws specific test, the adrenaline content of the urine of some normal individuals was considerably higher than has been reported by those using the von Euler technic (adsorption at an alkaline pH, elution and bioassay). One patient with myocardial infarction showed highly significant amounts on four occasions. The marked elevation in the Kroneberg-Schümann catechol ratio for hypertension patients as compared with normals, reported by these authors, was not confirmed by our findings. In three cases of myocardial infarction the ratio was elevated. Our ratios for normals confirm the original work.

Paroxysmal and persistent hypertension in association with lesions of the adrenal glands

Abstract This paper summarizes, first, the clinical instances that we have been able to find in the literature of hypertension ascribed to hyperplasia or tumor of the cortex of the adrenal gland. To this group we have added one case of our own which is unlike other reported instances in that marked hyperplasia of the adrenal cortex and a cortical adenoma were apparently responsible for the development of hypertension in a patient with evident cardiac decompensation. The second presentation records the story of a patient in whom a diagnosis of pheochromocytoma of the adrenal medulla was made, with complete disappearance of the symptoms following surgical removal of the tumor.

Auscultatory evidence of cardiac rupture.

Abstract An instance of rupture of the anterior wall of the left ventricle is described, during which time the entire cycle of changes from normal heart sounds through the period of rupture and until cessation of heart action, is recorded. A diagnosis of ruptured ventricular wall was entered on the hospital record at that time; it was substantiated by post-mortem examination.

Bundle-branch block with periods of normal intraventricular conduction: Report of an unusual case☆

Abstract The electrocardiographic tracings taken from a sixty-six-year-old man who had no cardiac symptoms showed a typical bundle-branch block which abruptly disappeared with the spontaneous occurrence of 2:1 A-V block, and which disappeared after cardiac slowing, the result of indirect vagal stimulation. This is the fourth instance of proved type 2 bundle-branch block to be reported. It is believed that the conduction disturbance in this instance was primarily the result of fatigue of the bundle and that the depressed tissue was small in extent.

A clinical and pathological study of coronary sclerosis: Its incidence in hypertension and angina pectoris

Abstract 1. 1. Clinically detectable coronary sclerosis occurred in 44.5 ± 3.8 per cent of 155 unselected hypertensive patients, distributed as follows: angina pectoris and cardiac asthma, each 12.2 per cent; electrocardiographic abnormalities only (from a total of 117 tracings) 19.6 per cent; coronary occlusion, 5.1 per cent. 2. 2. In 65 hypertensive patients coming to necropsy, the clinical diagnosis of coronary sclerosis was substantiated in 97 ± 2.8 per cent of the instances in which the diagnosis was made. However, the condition was likewise present in 66.6 ± 8.5 per cent of the remaining patients in whom it was not suspected. 3. 3. Coronary disease in these patients was almost uniformly accompanied by intense vascular changes in other areas of the vascular bed as disclosed by both clinical examination and post-mortem studies. The coronary arteries, however, were occasionally spared in instances of widespread vascular disease. 4. 4. The electrocardiographic findings in this group of patients are contrasted with those encountered in patients having angina pectoris. The influence of uncomplicated hypertension and of coronary sclerosis upon the electrocardiogram is discussed.