Franziska Götz
Humboldt State University
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Featured researches published by Franziska Götz.
Neuroendocrinology | 1993
Franziska Götz; G. Dörner; Uwe Malz; Wolfgang Rohde; F. Stahl; Michael Schulze; Andreas Plagemann
Nervous, endocrine and immune systems are regarded as a complex functional unit, interacting by their specific chemical messengers – neurotransmitters, systemic hormones and hormone-like mediators of immune cells (cytokines). Cytokines are known to affect several endocrine axes. Interleukin-lβ (IL) was administered in rats intraperitoneally twice daily from day 17 to 21 of pregnancy. Some of the IL-treated mothers were rapidly decapitated 1.5 h after the last injection. The fetuses were delivered by cesarean section. Maternal plasma CRF, ACTH and corticosterone were found to be significantly elevated. Fetal adrenal and thymus weights were lower, and plasma corticosterone did not differ from controls. Fetal plasma testosterone was decreased in males, androstenedione was increased in females. Open-field testing revealed a higher total locomotor activity of IL offspring than of controls. IL offspring showed worse results in Skinner box learning than controls. Sexual behavior was only affected in males, showing a higher percentage of female-type lordosis behavior after castration and estrogen treatment compared to controls. At the age of 6 months responsiveness to ‘novel-environment stress’ of IL groups was significantly lower than that of controls in terms of plasma corticosterone. These results indicate that prenatal treatment with IL-lβ results in long-lasting alterations in psychomotor development, behavior as well as in the neuroendocrine system.
Journal of Steroid Biochemistry | 1987
G. Dörner; F. Döcke; Franziska Götz; Wolfgang Rohde; F. Stahl; Renate Tönjes
The positive estrogen feedback was found to be a relatively sex-specific reaction of the hypothalamo-hypophyseal system in rats as well as in human beings. It is dependent--most of all--on the estrogen convertible androgen level during sexual brain differentiation, but also on an estrogen priming effect in adulthood. The lower the estrogen convertible androgen or primary estrogen level during brain differentiation, the higher is the evocability of a positive estrogen action on LH secretion in later life. In clinical studies, we were able to induce a positive estrogen feedback on LH secretion in most intact homosexual men in clear-cut contrast to intact hetero- or bisexual men. These findings were strongly confirmed by Gladue and associates. In addition, the evocability of a positive estrogen feedback was also demonstrable in most homosexual male-to-female transsexuals in significant contrast to hetero- or bisexual male-to-female transsexuals. These findings suggest that homosexual males possess, at least in part, a predominantly female-differentiated brain, which may be caused by a low estrogen convertible androgen level during brain organization. Recently, the following relations were found between sex hormone levels during brain differentiation and sex-specific responses in adulthood: (1) estrogens--which are mostly converted, however, from androgens--are responsible for the sex-specific organization of gonadotrophin secretion and hence the evocability of a positive estrogen feedback in later life; (2) estrogens and androgens, occurring during brain differentiation, predetermine synergistically sexual orientation and (3) androgens--without conversion to estrogens--are responsible for the sex-specific organization of gender role behaviour in later life. Furthermore, the organization periods for sex-specific gonadotrophin secretion, sexual orientation and gender role behaviour are not identical but overlapping. Thus, combinations as well as dissociations between deviations of the neuroendocrine organization of sex-specific gonadotrophin secretion, sexual orientation and gender role behaviour are conceivable. Most recently, female-type sexual orientation could be converted to male-type sexual orientation in adult rats by administration of the dopamine agonist and serotonin antagonist lisuride.
Experimental and Clinical Endocrinology & Diabetes | 2009
Franziska Götz; Renate Tönjes; J. Maywald; G. Dörner
Lisuride induces in juvenile male and especially in female rats a significant increase of the initiating activity in tests on social play-fighting behaviour. In neonatally castrated as well as in prenatally stress exposed males, castrated in adulthood, which exhibit under androgen alone bisexual or even predominantly heterotypical sexual behaviour, additional treatment with lisuride resulted in a temporary normalization of sexual orientation in the homotypical male direction. In castrated androgen treated females, lisuride induces a partial conversion of sexual orientation to heterotypical male direction.
Archive | 1988
G. Dörner; Andreas Plagemann; J. Rückert; Franziska Götz; Wolfgang Rohde; F. Stahl; U. Kürschner
When adult female rats (first generation) were injected with 30 mg of streptozotocin per kg body weight (b.w.) on the first day of pregnancy they developed a mild gestational diabetes. Their offspring (second as well as third generation) displayed increased plasma insulin levels in neonatal life and hypoplasia of the hypothalamic ventromedial nuclei throughout life as well as altered hypothalamic monoamine and β-endorphin concentrations. In adulthood, the offspring exhibited decreased tolerance and increased susceptibility to streptozotocin diabetes, associated with enhanced spleen cell cytotoxicity against β-cells. Such teratogenetic diabetes susceptibility is only transmitted on the maternal side via gestational diabetes, leading to pre- or early postnatal hyperinsulinism. Thus, hyperinsulinism during brain organization, produced by impaired glucose tolerance in pregnancy, is a predisposing teratogenetic factor for the development of diabetes in the offspring. Our experimental data are in agreement with clinical findings: (1) Diabetes transmission between generations was found to be 2–3 times higher on the maternal side than on the paternal side. (2) Subjects born in periods with high food supply showed a significantly higher diabetes prevalence than those born in periods with shortage of food supply. (3) A significantly decreased prevalence of childhood-onset diabetes could be achieved in Berlin/GDR since 1973 by improving systematically diagnostic and therapeutic measures for gestational diabetics.
Experimental and Clinical Endocrinology & Diabetes | 2009
Andreas Plagemann; I. Heidrich; Franziska Götz; Wolfgang Rohde; G. Dörner
Experimental and Clinical Endocrinology & Diabetes | 2009
Andreas Plagemann; I. Heidrich; Franziska Götz; Wolfgang Rohde; G. Dörner
Experimental and Clinical Endocrinology & Diabetes | 2009
G. Dörner; Andreas Plagemann; J. Rückert; Franziska Götz; Wolfgang Rohde; F. Stahl; U. Kürschner; J. Gottschalk; A. Mohnike; E. Steindel
Neuro endocrinology letters | 2001
G. Dörner; Franziska Götz; Wolfgang Rohde; Andreas Plagemann; Rolf Lindner; Hartmut Peters; Zhara Ghanaati
Experimental and Clinical Endocrinology & Diabetes | 2009
Wolfgang Rohde; T. Ohkawa; Franziska Götz; F. Stahl; Renate Tönjes; Takeshita S; Arakawa S; Kambegawa A; K. Arai; S. Okinaga
Cytokine | 1999
Alexandra Bumiller; Franziska Götz; Wolfgang Rohde; Günther Dörner