Fraser D. Munro

Long-gap esophageal atresia treated by growth induction: the biological potential and early follow-up results

This study had two purposes. The first was to determine whether the growth procedure would allow true primary repairs of the most severe end of the esophageal atresia (EA) spectrum with the longest gaps (LG) and most rudimentary lower esophageal segments. The second goal was to provide the first short- to mid-term (3-12 years) follow-up data on the esophageal function and quality of life (QOL) data on the patients in this series. From our series of 60 LG-EA patients who underwent a growth procedure, 42 had the true primary esophageal repair completed 3 years ago. Among these, 18 had gaps over 6 cm, and for 6, only a rudimentary lower esophagus existed well below the diaphragm. No patient was turned down and all had primary repairs. These results suggest that even the most rudimentary segment has the potential to achieve normal size and that the full EA spectrum can have a primary repair. Our follow-up studies indicated that the esophageal function of these previously grown segments was very good. All contacted (40) were eating normally with only 3 receiving supplemental g-tube feeds because of other significant defects. We have actively treated significant reflux and 41/42 had fundoplication. By endoscopy (N = 15) no esophagitis was visible, but on biopsy, mild inflammation was found in 3. No conditions were found which would suggest that there would be a late deterioration or adverse consequences would arise. Based on these ongoing evaluations, the outlook seems very favorable for a good long-term QOL.

Delayed presentation of handlebar injuries in children

Initial assessment of children with abdominal trauma from bicycle handlebars may provide false reassurances

Effect of Patient Weight and Anesthetic Technique on CO2 Excretion During Thoracoscopy in Children Assessed by End-Tidal CO2

AIM The aim of this study was to review the changes in CO(2) excretion and anesthetic management during thoracoscopy in children. METHODS We analyzed end-tidal carbon dioxide concentration (EtCO(2); kPa) during CO(2) pneumothorax. EtCO(2) was measured on a continuous basis by using a positive sampling system and recorded every 10 minutes. Baseline and highest EtCO(2) were used to derive the maximum change in the intraoperative period. EtCO(2) was also analyzed in three time periods: (1) preinsufflation, (2) during insufflation of CO(2) into the chest, and (3) after desufflation. Core temperature was also recorded as an index of thermoregulation. Data are presented as the mean +/- standard error of the mean. Differences within time periods were compared by using paired t tests or repeated measures analysis of variance. Correlation between changes in EtCO(2) and patient demographics was performed by using linear regression. The pattern of change was compared to children undergoing laparoscopy. RESULTS Median age was 1.9 years (range, 1 day to 15 years). EtCO(2) increased significantly from preinsufflation 5.1 +/- 0.2 to 6.4 +/- 0.3 during insufflation (P < 0.01); values were still significantly elevated after desufflation 6.4 +/- 0.4 (P < 0.01). Single-lung ventilation was associated with higher EtCO(2) levels during insufflation than with two-lung ventilation (P = 0.02). Maximum change in the EtCO(2) in the group undergoing one-lung ventilation negatively correlated to patient weight (r(2) = 0.25, P = 0.02); this correlation was not present with two-lung ventilation (r(2) = 0.02, P = 0.84). Laparoscopy increased EtCO(2) from 4.7 +/- 0.2 preinsufflation to 5.3 +/- 0.2 (P < 0.001) during and decreased to 4.8 +/- 0.2 postdesufflation (P = 0.60). There was a significant increase in core temperature from 35.9 +/- 0.3 to 36.9 +/- 0.2 postoperatively (P = 0.007). CONCLUSIONS There is a significant increase in EtCO(2) in children undergoing thoracoscopy, which is higher than during laparoscopy. Changes in EtCO(2) are larger in smaller children undergoing single-lung ventilation. Thoracoscopy may preserve intraoperative thermoregulation.

The role of laparoscopy in the management of lower gastro-intestinal bleeding

This report describes three cases of significant lower gastro-intestinal haemorrhage caused by a bleeding Meckels diverticulum. In the first two cases a pre-operative technetium-pertechnetate or Meckels scan was negative or inconclusive, and in the third case no Meckels scan was carried out. The diagnosis was established at laparoscopy in all three cases and in each case the diverticulum was excised extracorporeally.

Congenital colonic atresia: should primary anastomosis always be the goal?

Abstract.We report 4 cases of the rare condition, congenital colonic atresia, presenting over 9 years. Two patients had dilated loops of bowel noted on routine ante-natal ultrasound. Three had primary anastomosis for lesions in transverse or distal descending colon and one had a staged procedure with colostomy formation. All had type III atresia. One patient had an early leak following primary colo-colic anastomosis for atresia extending from the hepatic flexure to the sigmoid colon. If it is desired to preserve the proximal colon in a right sided lesion with significant loss of colonic length then primary anastomosis may not be safe and we would advocate a staged procedure. Otherwise we would support current moves towards primary anastomosis in this condition. We also urge early investigation in all patients who exhibit intestinal dilatation on antenatal ultrasound.

Regionally acquired intestinal failure data suggest an underestimate in national service requirements

Objectives, setting and patients: With complete case referral for prolonged parenteral nutrition (PN) beyond term equivalent, serving a stable population of 1.25 million people, we describe the long-term outcome and survival of patients referred to an intestinal failure (IF) nutrition support team over the first 8 years of existence at a regional paediatric centre, and extrapolate to potential numbers of national home parenteral nutrition (HPN) cases and intestinal transplantation data. Design and outcome measures: Retrospective analysis detailing patient demographics, interventions, use of HPN, occurrence of intestinal failure-associated liver disease (IFALD), and outcomes of enteral adaptation, survival, and referral for and receipt of organ transplantation. Results: 23 patients were referred over 8 years, 20 being PN dependent within the neonatal period. Diagnoses included short bowel syndrome (SBS) (18), neuromuscular abnormalities (4) and congenital enterocyte disorder (1). 12 696 days of PN were delivered with 314 confirmed episodes of sepsis at a median of 12 episodes per patient. 144 central venous catheters (CVCs) were required at a median of four per patient. IFALD occurred in 17 (73%) patients, with 10 (44%) referred for transplant assessment. Thirteen (56%) children received HPN. Overall mortality was 44%. A significant predictor for survival in the SBS group was residual bowel >40 cm (82% vs 28%, p = 0.049). Conclusions: Survival for IF at 56% was lower than reported from non-UK supra-regional centres, and nationally collected data, possibly reflecting pre-selected referral populations. Data from regional centres with complete ascertainment may be important both when counselling parents and when planning regional and national HPN and IF specialist services.

Thrombolysis with low dose tissue plasminogen activator.

Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions of tissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.

Congenital neuroblastoma presenting with paraplegia

A girl presented with paraplegia at birth. A magnetic resonance scan showed an abdominal neuroblastoma with intraspinal extension. Treatment by chemotherapy did not produce any improvement in the neurological signs. Review of previously reported cases suggests the outlook for neurological recovery is poor regardless of treatment.

Urinary ascites in infancy: varied etiologies

Three cases of urinary ascites are presented, each with a different underlying aetiology. The age and modes of presentation also varied and management strategies were accordingly tailored to each patients clinical requirements. All 3 patients survived and subsequently were discharged with good renal function. Although a rare condition, infants with urinary ascites can present as clinical emergencies in need of prompt resuscitation with subsequent drainage of the urine and decompression of the urinary tract. The ultimate management regime will vary and depend upon site of urinary extravasation and underlying aetiology.

Intraoperative Upper GI Endoscopy Ensures an Adequate Laparoscopic Heller's Myotomy

INTRODUCTION In this article, we present our case series of laparoscopic Hellers myotomies. These were all performed with the aid of intraoperative upper gastrointestinal (GI) endoscopy. MATERIALS AND METHODS During a 7-year period, 5 patients underwent a laparoscopic Hellers myotomy. There were 4 male patients and 1 female, with an average age of 12.1 years at operation (range, 9.3-14.9). One 14-year-old boy had had a laparoscopic Hellers procedure performed elsewhere and presented with severe dysphagia while undergoing orthopedic surgery in our hospital. His myotomy had been inadequate, and an intraoperative endoscopy had not been performed. All patients had preoperative upper GI contrast studies performed to confirm the diagnosis of achalasia. Two patients had manometry in addition to the contrast study. One patient had been treated with balloon dilatation preoperatively and another with botox injections. Endoscopy was performed pre- and postmyotomy to ensure adequacy. RESULTS There were no cases of intraoperative mucosal perforation or conversions to an open procedure. Sixty percent of patients required extension of the myotomy after intraoperative endoscopy. All patients had an uneventful, complication-free postoperative recovery. CONCLUSION We feel that the addition of endoscopy during laparoscopic Hellers myotomy confers a significant advantage in ensuring that the myotomy is adequate. In our experience, the outcome has been excellent even after previous balloon dilatation or submucosal botox injections.