Fred Bruschweiler

Structure of the bufadienolide bufotalin

Mass spectral and 1H n.m.r. evidence, coupled with degradation of bufotalin to 3β-acetoxybufotalien (II), in turn prepared by total synthesis, provide unequivocal support for the assignment of structure (I) to bufotalin.

Synthesis of bufalin

A new total synthesis of resibufogenin and bufalin using digitoxigenin, represents the first chemical transformation of a cardenolide to a bufadienolide.