Fred Pinheiro

Root Resorption in Orthodontics - Genetic Susceptibility?

Recent evidence suggests that lncRNAs take part in cancer progression and metastasis through influencing several oncogenic pathways. However, our efforts to find clinically relevant cancer associated functional lncRNAs on global scale are still lacking. By employing a nascent RNA capture sequencing we identified 1145 S-phase-associated lncRNAs. Out of 1145, 571 lncRNAs showed significant differential expression at least in one tumor type across pan cancer TCGA datasets. Interestingly, 73% of these transcripts exhibit higher expression in tumors. Using an integrated multistep statistical pipeline on 14 pan-cancer datasets, we identified 520 independent prognostic markers. Based on our high-throughput transcriptomic analysis of S-phase enriched lncRNA across pancancer TCGA datasets followed by large-scale functional and clinical investigations, we provide a comprehensive list of lncRNA-based oncogenic drivers with potential prognostic value.