Fred Valeriote
Washington University in St. Louis
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Publication
Featured researches published by Fred Valeriote.
European Journal of Cancer | 1981
Giovanni Santelli; Fred Valeriote; Teresa J. Vietti; Dean Coulter
The cytotoxic effect of the combination of cyclophosphamide and 5-fluorouracil against AKR and L1210 leukemias was quantitated by a spleen colony assay. We used different sequences, a number of doses of each agent, and different intervals between the agents and noted different degrees of synergistic cell-kill. By proper scheduling of these agents, greater than 100-fold increase in cell killing was noted, an effect not demonstrable for normal hematopoietic stem cells. However, the pattern of response for AKR was opposite to that for L1210 leukemia; we suggest that this reflects a difference in the metabolism of 5-FU.
Biochemical Pharmacology | 1977
Mark Edelstein; Fred Valeriote
Abstract Anomalous results of dose-survival curves from studies in vitro with the nucleoside analogue 1-β- d -arabinofuranosylcytosine (ara-C) led to a consideration of distribution of drug between cells and overlying culture media. The investigations presented here, using both a biological and a radioisotope technique, demonstrate that approximately 0.5 to 1 per cent of an initial dose of ara-C is released within 1 hr into the media from treated cells and the culture dish after an initial wash.
Journal of the National Cancer Institute | 1971
Teresa J. Vietti; Faye Eggerding; Fred Valeriote
Cancer Research | 1974
Gerald Medoff; Fred Valeriote; Richard G. Lynch; David Schlessinger; George S. Kobayashi
Journal of the National Cancer Institute | 1978
Giovanni Santelli; Fred Valeriote
Journal of the National Cancer Institute | 1981
Gerald Medoff; Fred Valeriote; Julia Dieckman
Cancer Research | 1974
Aly Razek; Teresa J. Vietti; Fred Valeriote
Cancer Research | 1979
Fred Valeriote; Gerald Medoff; Julia Dieckman
Cancer Research | 1975
Mark Edelstein; Teresa J. Vietti; Fred Valeriote; Kathy Atwood
Cancer Research | 1972
Aly Razek; Fred Valeriote; Teresa J. Vietti