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Dive into the research topics where Fred Valeriote is active.

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Featured researches published by Fred Valeriote.


European Journal of Cancer | 1981

Cytotoxic effect of 5-fluorouracil plus cyclophosphamide against transplantable leukemias☆

Giovanni Santelli; Fred Valeriote; Teresa J. Vietti; Dean Coulter

The cytotoxic effect of the combination of cyclophosphamide and 5-fluorouracil against AKR and L1210 leukemias was quantitated by a spleen colony assay. We used different sequences, a number of doses of each agent, and different intervals between the agents and noted different degrees of synergistic cell-kill. By proper scheduling of these agents, greater than 100-fold increase in cell killing was noted, an effect not demonstrable for normal hematopoietic stem cells. However, the pattern of response for AKR was opposite to that for L1210 leukemia; we suggest that this reflects a difference in the metabolism of 5-FU.


Biochemical Pharmacology | 1977

Retention of 1-β-d-arabinofuranosylcytosine in vitro—: A source of experimental error

Mark Edelstein; Fred Valeriote

Abstract Anomalous results of dose-survival curves from studies in vitro with the nucleoside analogue 1-β- d -arabinofuranosylcytosine (ara-C) led to a consideration of distribution of drug between cells and overlying culture media. The investigations presented here, using both a biological and a radioisotope technique, demonstrate that approximately 0.5 to 1 per cent of an initial dose of ara-C is released within 1 hr into the media from treated cells and the culture dish after an initial wash.


Journal of the National Cancer Institute | 1971

Combined Effect of X Radiation and 5-Fluorouracil on Survival of Transplanted Leukemic Cells

Teresa J. Vietti; Faye Eggerding; Fred Valeriote


Cancer Research | 1974

Synergistic effect of amphotericin B and 1,3-bis(2-chloroethyl)-1-nitrosourea against a transplantable AKR leukemia.

Gerald Medoff; Fred Valeriote; Richard G. Lynch; David Schlessinger; George S. Kobayashi


Journal of the National Cancer Institute | 1978

In Vivo Enhancement of 5-Fluorouracil Cytotoxicity to AKR Leukemia Cells by Thymidine in Mice

Giovanni Santelli; Fred Valeriote


Journal of the National Cancer Institute | 1981

Potentiation of Anticancer Agents by Amphotericin B

Gerald Medoff; Fred Valeriote; Julia Dieckman


Cancer Research | 1974

Optimum Time Sequence for the Administration of Vincristine and Cyclophosphamide in Vivo

Aly Razek; Teresa J. Vietti; Fred Valeriote


Cancer Research | 1979

Potentiation of Anticancer Agent Cytotoxicity against Sensitive and Resistant AKR Leukemia by Amphotericin B

Fred Valeriote; Gerald Medoff; Julia Dieckman


Cancer Research | 1975

The Enhanced Cytotoxicity of Combinations of 1-β-d-Arabinofuranosylcytosine and Methotrexate

Mark Edelstein; Teresa J. Vietti; Fred Valeriote; Kathy Atwood


Cancer Research | 1972

Survival of Hematopoietic and Leukemic Colony-forming Cells in Vivo following the Administration of Daunorubicin or Adriamycin

Aly Razek; Fred Valeriote; Teresa J. Vietti

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Teresa J. Vietti

Washington University in St. Louis

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Gerald Medoff

Washington University in St. Louis

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Julia Dieckman

Washington University in St. Louis

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Mark Edelstein

Washington University in St. Louis

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Aly Razek

Washington University in St. Louis

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Giovanni Santelli

Washington University in St. Louis

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Cary A. Presant

Washington University in St. Louis

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Richard G. Lynch

Washington University in St. Louis

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Sandra Tolen

Washington University in St. Louis

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David Schlessinger

National Institutes of Health

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