Frederick J. Moore

A study of the beneficial effects of anticoagulant therapy in congestive heart failure.

Excerpt Thromboemboli are a frequent cause of death in patients with congestive heart failure. In 565 patients with rheumatic heart disease and congestive heart failure, autopsied at the Los Angele...

Clinical Studies of Long-Term Estrogen Therapy in Men with Myocardial Infarction

Conclusions and summary 1. In a clinical trial men with coronary artery disease who had recovered from a frank myocardial infarction were randomly treated with Lynoral (ethinyl estradiol), Anvene, Premarin, or a placebo. The 3 estrogen preparations were used in small well-tolerated doses of comparable potency as indicated by mild breast tenderness. 2. No untoward effects of the treatment were observed in up to 60 months of continuous treatment. Changes in libido were rarely noted. 3. Premarin therapy significantly improved survival, particularly in the first 2 years of treatment. Lynoral (ethinyl estradiol) and Anvene had no effect on survival as compared with placebo treatment. 4. Subclasses of patients most likely to benefit from Premarin therapy were those with relatively poor initial prognosis: men under age 55, who had had a first myocardial infarction, and with complications of arteriosclerotic heart disease present. 5. Lynoral (ethinyl estradiol) and Anvene significantly lowered the cholesterol-phospholipid ratio. Premarin had no such effect. 6. There is no necessary correlation between physical response (e.g., breast tenderness), serum lipid and survival effects of estrogen preparations in the male recovering from myocardial infarction: altering of the serum lipids does not necessarily improve survival, and survival may be improved without altering of the serum lipids.

Comparison of Chlorine and Ozone as Virucidal Agents of Poliomyelitis Virus.

Conclusions and Summary 1. Gaseous chlorine and hypochlorite in residual amounts of 0.5 ppm failed to inactivate a 1:1000 dilution of Le strain of poliomyelitis virus after an exposure of 90 minutes but inactivated the virus by 180 minutes. These results compare favorably with those of Kempf and Soule in working with the MV strain of virus. 2. Ozone in residual amounts not exceeding 0.45 ppm, inactivated a 1:1000 dilution of Le virus in 2 minutes and a 1:100 dilution of the same virus in 45 minutes. A 1:10 dilution of MV virus was not inactivated in 30 minutes and a 1:10 dilution of Le virus was not inactivated in 45 minutes. The extra amount of brain material in the lower dilutions constitutes an excess of organic matter which probably accounts for the longer time necessary for inactivation of virus at these dilutions. It is observed from these results that an identical dilution of the same strain and pool of poliomyelitis virus when exposed to chlorine in residual amounts ranging from 0.5-1.0 ppm and to ozone in residual amounts between 0.05-0.45 ppm under the same controlled experimental conditions was inactivated almost immediately by ozone, i.e., within 2 minutes, while an interval ranging between 11/2 hours and 3 hours was required for inactivation by chlorine. Thompson12 in a recent review of the significance of the findings concerning the occurrence of poliomyelitis virus in intestinal contents and sewage and of its inactivation by current water purification procedures suggests either “superchlorination” or that “ozone treatment might be effective.” The germicidal effects of ozone have been noted in the past but recent quantitative determinations have not been reported and its effect on viruses has not been observed.

Collagen and hexosamine content of femurs of rats.

Summary The collagen and hexosamine contents of the femurs of growing rats were determined. Regression equations were derived upon the basis that there is a linear relationship between the logarithm of body weight and of femur length and the logarithm of the quantity of collagen and hexosamine. Rate of collagen deposition decreases somewhat as the animal grows. Rate of deposition of hexosamine-containing material, decreases markedly so that the ratio of hexosamine to collagen decreases with growth.

Effect of premarin on survival in men with myocardial infarction.

Conclusion The incidence of deaths due to arteriosclerotic heart disease is being compared in men recovered from myocardial infarction and treated 75 days or more with either Premarin or no estrogen (control), allocation of treatments being randomized. Survival rate in those receiving Premarin is significantly higher than in controls.

EFFECTS OF LONG-TERM ESTROGEN THERAPY ON SERUM CHOLESTEROL AND PHOSPHOLIPIDS IN MEN WITH MYOCARDIAL INFARCTION

Excerpt It has been well established1-8that administration of estrogen to men or women with myocardial infarction tends to raise the serum phospholipids and to lower the serum cholesterol and the c...

Production of acute rheumatic-like heart lesions in mice.

Summary Acute rheumatic-like heart lesions have been produced in mice by parenteral injection of egg white on repeated occasions. Minimal lesions may also occur in untreated mice, possibly as a result of spontaneous sensitization and shocking by natural contact with protein. There was no apparent relation between the severity of clinical anaphylaxis and the severity of the pathologic changes in the heart.

The familial incidence of rheumatic fever: II. A statistical study of the familial and personal history of rheumatic fever

Abstract 1. 1. Three per cent of those making up the normal control groups had a personal history of rheumatic fever earlier in life. 2. 2. An attack of rheumatic fever earlier in life tends to facilitate a later attack, but this difference is not great. 3. 3. The occurrence of rheumatic fever in the family increases the risk of the individual developing the disease while still in contact with the family, but not after he is separated from the family. There does not, therefore, appear to be a strong and inherited susceptibility. The occurrence of multiple cases in families could be explained either on the basis of common environment or contagion. In the light of the widely accepted relationship of streptococcal infection to rheumatic fever, and the lack of agreement concerning the roles of social, economic, and geographic factors, we prefer to look on these data as indicating the dominant role of contagion in the development of rheumatic fever.

The familial incidence of rheumatic fever

Abstract 1.1. Three per cent of those making up the normal control groups had a personal history of rheumatic fever earlier in life. 2.2. An attack of rheumatic fever earlier in life tends to facilitate a later attack, but this difference is not great. 3.3. The occurrence of rheumatic fever in the family increases the risk of the individual developing the disease while still in contact with the family, but not after he is separated from the family. There does not, therefore, appear to be a strong and inherited susceptibility. The occurrence of multiple cases in families could be explained either on the basis of common environment or contagion. In the light of the widely accepted relationship of streptococcal infection to rheumatic fever, and the lack of agreement concerning the roles of social, economic, and geographic factors, we prefer to look on these data as indicating the dominant role of contagion in the development of rheumatic fever.

Emergency Sterilization of Drinking Water with Heteropolar Cationic Antiseptics

Although there are many practical uses for antiseptics which are effective against cysts of Endamoeba histolytica, one of the most important and difficult is the emergency sterilization of drinking water under military combat conditions. Various halogen preparations have not been entirely satisfactory because they tend to be inactivated by organic nitrogenous material and by alkalinity. Since natural waters encountered in the field may sometimes contain very high concentrations of organic nitrogenous material or may be alkaline, and since military emergency conditions in the field require uniform dosage, it is necessary to use the halogens in high initial concentrations under all conditions so that they may prove effective even under the worst conditions. These high concentrations of the halogens are distasteful and may not be entirely without toxicity. The antiseptic activity of certain heteropolar cationic compounds, or synthetic, cationic detergents, was described in 1935 by Domagk (1) and Katz and Lipsitz (2).