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Dive into the research topics where Friedhelm Balkenhohl is active.

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Featured researches published by Friedhelm Balkenhohl.


Zeitschrift für Naturforschung B | 1999

A Short and Productive Synthesis of Racemic α-Lipoic Acid

Friedhelm Balkenhohl; Joachim Dr. Paust

(R )-α-Lipoic acid is synthesized in seven steps from the base chemicals methyl acetoacetate or Meldrum’s acid and monomethyl adipate. The key steps are the introduction of the stereogenic center by fermentative or homogeneously catalyzed hydrogenation of 3-oxooctanedioic acid diester to (3S)-3-hydroxyoctanedioic acid diester and its regioselective reduction to (6S)-6 ,8-dihydroxyoctanoic acid ester. The overall yield of (R )-α-lipoic acid, starting from 3-oxooctanedioic acid diester, is 40%.


Journal Fur Praktische Chemie-chemiker-zeitung | 1997

Optisch aktive Amine durch Lipase‐katalysierte Methoxyacetylierung

Friedhelm Balkenhohl; Klaus Ditrich; Bernhard Hauer; Wolfgang Ladner


Archive | 1996

Racemate separation of primary and secondary heteroatom-substituted amine by enzyme-catalysed acylation

Friedhelm Balkenhohl; Klaus Ditrich; Christoph Nübling


Archive | 1994

Resolution of the racemates of primary and secondary amines by enzyme-catalyzed acylation

Friedhelm Balkenhohl; Bernhard Hauer; Wolfgang Ladner; Uwe Pressler; Christoph Nübling


Archive | 1994

Racemate cleavage of primary and secondary amines by enzyme-catalysed acylation

Friedhelm Balkenhohl; Bernhard Hauer; Wolfgang Ladner; Uwe Pressler; Christoph Nübling


Archive | 1991

Process for the preparation of esters of (6s)-6,8-dihydroxyoctanoic acid.

Friedhelm Balkenhohl; Joachim Paust


Archive | 1996

Separation of optically active amides

Klaus Ditrich; Friedhelm Balkenhohl; Wolfgang Ladner


Archive | 1993

Preparation of calcium L-ascorbate 2-phosphate

Klaus Kaiser; Friedhelm Balkenhohl; Joachim Paust


Archive | 1996

Resolution of racemates of primary and secondary heteroatom-substitued amines by enzyme-catalyzed acylation

Friedhelm Balkenhohl; Klaus Ditrich; Christoph Nübling


Archive | 1995

Preparation of (6s)-6,8-dihydroxyoctanoic esters

Friedhelm Balkenhohl; Joachim Paust

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Joachim Paust

University of Göttingen

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Uwe Pressler

University of Tübingen

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