Fritz Bliss
Hoffmann-La Roche
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Publication
Featured researches published by Fritz Bliss.
Bioorganic & Medicinal Chemistry Letters | 2013
Henrietta Dehmlow; Ruben Alvarez Sanchez; Stephan Bachmann; Caterina Bissantz; Fritz Bliss; Karin Conde-Knape; Martin Graf; Rainer E. Martin; Ulrike Obst Sander; Susanne Raab; Hans Richter; Sabine Sewing; Urs Sprecher; Christoph Ullmer; Patrizio Mattei
A series of non-steroidal GPBAR1 (TGR5) agonists was developed from a hit in a high-throughput screening campaign. Lead identification efforts produced biphenyl-4-carboxylic acid derivative (R)-22, which displayed a robust secretion of PYY after oral administration in a degree that can be correlated with the unbound plasma concentration. Further optimisation work focusing on reduction of the lipophilicity provided the 1-phenylpiperidine-4-carboxylic acid derivative (R)-29 (RO5527239), which showed an improved secretion of PYY and GLP-1, translating into a significant reduction of postprandial blood glucose excursion in an oral glucose tolerance test in DIO mice.
Tetrahedron Letters | 2009
Fabienne Hoffmann-Emery; Roland Jakob-Roetne; Alexander Flohr; Fritz Bliss; Reinhard Reents
Archive | 2005
Fritz Bliss; Michel Lalonde; Rudolf Schmid; Rene Trussardi
Archive | 2014
Bjoern Bartels; Fritz Bliss; Zbinden Katrin Groebke; Matthias Koerner
Archive | 2013
Bjoern Bartels; Fritz Bliss; Philipp Cueni; Christophe Pfleger; Ulrich Zutter
Archive | 2017
Bjoern Bartels; Christophe Pfleger; Fritz Bliss; Philipp Cueni; Ulrich Zutter
Archive | 2016
Urs Schwitter; Fritz Bliss; Michael Kammerer; Florence Tixeront
Archive | 2014
Ulrich Zutter; Fritz Bliss; Philipp Cueni; Christophe Pfleger; Bjoern Bartels
Archive | 2011
Stephan Bachmann; Fritz Bliss; Ralph Diodone; Stefan Hildbrand; Michael Kammerer; Christophe Pfleger; Reinhard Reents; Michelangelo Scalone
Archive | 2005
Fritz Bliss; Michel Lalonde; Rudolf Schmid; Rene Trussardi
