Fritz Schaub

Synthesis and acaricidal activity of 4-pyrimidinyloxy- and 4-pyrimidinylaminoethylphenyl dioxolanes and oxime ethers

Novel types of mitochondrial respiration inhibitors at complex I, with emphasis on acaricidal activity, have been designed and prepared. The synthetic approach to these 4-pyrimidinylphenyl ethyl ethers and amines with a specific ketal or oxime function in the phenyl side chain is outlined. Bioassays demonstrate their high potential against important spider mites, like Tetranychus urticae and Panonychus ulmi. Structure-activity relationship studies and several biological parameters are discussed.

Regio- and Stereoselective Alkoxycarbonylmethylenation of Partially Saturated Heterobicyclic Compounds: First Synthesis of 2-Substituted Quinazoline-8-acetic Acid Esters

Abstract The three-step synthesis of 2-substituted quinazol-8-yl acetates is described, introducing a completely new method for the regio- and stereoselective alkoxycarbonylmethylenation of tetrahydroquinazolines. # Novartis Crop Protection Ltd., Research Department, 975 California Avenue, Palo Alto, CA 94303, USA.