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Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids#R##N#Including the Proceedings of a Symposium on the Chemistry and Biochemistry of Prostanoids Held at The University of Salford, England, 10–14 July 1978 | 1979

ON THE EXISTENCE OF 6(9)-OXY-11,15- DIHYDROXYPROSTA-7,13-DIENOIC ACID

Charles J. Sih; Milton Zmijewski; Fu-Chih Huang; Raphael Lamed

ABSTRACT The presumed structure, 6(9)-oxy-11,15-dihydroxyprosta-7,13-dienoic acid ( 1 ) had been erroneously assigned. Moreover, there is no evidence to suggest its existence. Our experimental data are completely consistent with the contention that PGI2 was not isolated by Pace-Asciak and Wolfe (ref. 1) in 1971, and that their fraction A consisted of 6-keto-PGF1α as a mixture of keto and hemiketal forms.


Journal of the American Chemical Society | 1975

Letter: Preparation of (R)- and (S)-mevalonic acids.

Fu-Chih Huang; Lee Lf; R. S. D. Mittal; Ravikumar Pr; James Amigo Chan; Charles J. Sih; Caspi E; Eck Cr


Journal of the American Chemical Society | 1976

Letter: Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung(Eucommia ulmoides, Oliver).

Charles J. Sih; P.R. Ravikumar; Fu-Chih Huang; Carl Buckner; Howard W. Whitlock


Journal of the American Chemical Society | 1974

Studies on the incorporation of (2S, 3R)-(4,4,4-2H3)valine and (2S,3S)-4,4,4-2H3)Valine into beta-lactam antibiotics.

Harold C. Kluender; Fu-Chih Huang; Alan R. Fritzberg; Heinrich K. Schnoes; Charles J. Sih; Patricia Fawcett; E. P. Abraham


Journal of the American Chemical Society | 1975

Letter: The nonparticipation of alpha,beta-dehydrovalinyl intermediates in the formation of sigma-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine.

Fu-Chih Huang; James Amigo Chan; Charles J. Sih; Patricia Fawcett; E. P. Abraham


Journal of the American Chemical Society | 1978

Concerning the chemical identity of 6,9.alpha.-oxido-11.alpha.,15.alpha.-dihydroxyprosta-7(8),(E)13-dienoic acid

Charles J. Sih; Fu-Chih Huang


Biochemistry | 1976

The absolute configuration of the amino acids in delta-(alpha-aminoadipyl)cysteinylvaline from Penicillium chrysogenum.

James Amigo Chan; Fu-Chih Huang; Charles J. Sih


ChemInform | 1975

PREPARATION OF (R)- AND (S)-MEVALONIC ACIDS

Fu-Chih Huang; L. F. Hsu Lee; R. S. D. Mittal; P.R. Ravikumar; James Amigo Chan; Charles J. Sih; Eliahu Caspi; Charles R. Eck


ChemInform | 1975

THE NONPARTICIPATION OF ALPHA,BETA-DEHYDROVALINYL INTERMEDIATES IN THE FORMATION OF DELTA-(L-ALPHA-AMINOADIPYL)-L-CYSTEINYL-D-VALINE

Fu-Chih Huang; James Amigo Chan; Charles J. Sih; Patricia Fawcett; E. P. Abraham


ChemInform | 1976

ISOLATION AND SYNTHESIS OF PINORESINOL DIGLUCOSIDE, A MAJOR ANTIHYPERTENSIVE PRINCIPLE OF TU-CHUNG (EUCOMMIA ULMOIDES, OLIVER)

Charles J. Sih; P. R. Ravikumar; Fu-Chih Huang; C. Buckner; H. W. Jun. Whitlock

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Charles J. Sih

University of Wisconsin-Madison

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James Amigo Chan

University of Wisconsin-Madison

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Heinrich K. Schnoes

Wisconsin Alumni Research Foundation

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P.R. Ravikumar

University of Wisconsin-Madison

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R. S. D. Mittal

University of Wisconsin-Madison

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Howard W. Whitlock

University of Wisconsin-Madison

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Milton Zmijewski

University of Wisconsin-Madison

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Raphael Lamed

University of Wisconsin-Madison

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