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Featured researches published by Fu Jun Zhang.


Cancer Biology & Therapy | 2009

Short- to mid-term evaluation of CT-guided 125I brachytherapy on intra-hepatic recurrent tumors and/or extra-hepatic metastases after liver transplantation for hepatocellular carcinoma.

Fu Jun Zhang; Chuan Xing Li; Zhang Liang; Pei Hong Wu; De Chao Jiao; Guang Feng Duan

Objective: To evaluate the safety and short- to mid-term efficacy of CT-guided 125I brachytherapy on intra-hepatic recurrent tumors and/or extra-hepatic metastases after liver transplantation for hepatocellular carcinoma (HCC). Methods: From November 2004 to May 2008, ten patients with intra-hepatic recurrent tumors and/or extra-hepatic metastases after liver transplantation for HCC underwent 125I brachytherapy under the guidance of computed tomography. They were followed up for 4 to 44 months after brachytherapy and the treatments efficacy was evaluated. Results: Among the ten patients, one died of liver failure 15 months and one of renal failure 29 months after brachytherapy. All other eight patients survived till the end of the follow-up. Four of them presented good control of local tumor and no systemic recurrence; the other four survived with tumor presence, including three with recurrent tumors undergoing a second 125I brachytherapy and one switching to a biological target drug treatment. The local control rates after 4, 6, 12 and 24 months are 90.3%, 84.0%, 75.6% and 72.7% respectively. Procedure-related complications were minimal. Conclusion: CT-guided 125I brachytherapy is a safe and effective therapy on intra-hepatic recurrent tumors and/or extra-hepatic metastases after liver transplantation for hepatocellular carcinoma. It has the advantages of minimal invasion, significant short- to mid-term local control and minimal complications.


Asian Pacific Journal of Cancer Prevention | 2014

Lobaplatin-TACE Combined with Radioactive 125 I Seed Implantation for Treatment of Primary Hepatocellular Carcinoma

Sheng Peng; Qiu Xia Yang; Tao Zhang; Ming Jian Lu; Guang Yang; Zhen Yin Liu; Rong Zhang; Fu Jun Zhang

AIM To investigate the efficacy and safety of lobaplatin-transcatheter arterial chemoembolization (TACE) combined with radioactive 125I seed implantation in treatment of primary hepatocellular carcinoma (HCC). METHODS 75 patients with primary HCC were enrolled in the study, among them 43 receiving lobaplatin- TACE (TACE group) and 32 lobaplatin-TACE combined with 125I seed implantation (TACE+125I group). After treatment, the local remission rates and postoperative complications of two groups were compared using the Pearson Chi-square test. Overall survival in the two groups was calculated using Kaplan-Meier survival curves and the differences were tested using Log-rank test. RESULTS There were 7 cases of complete response (CR), 13 of partial response (PR), 6 of stable disease (SD) and 17 of progressive disease (PD) in the TACE group, with 13 cases of CR, 9 of PR, 5 of SD and 5 of PD in the TACE+125I group. The disease control rates of TACE and TACE+125I group were 60.5% (26/43) and 84.4% (27/32), respectively, with a significant difference between them (P < 0.05). The survival rates at 6, 12 and 18 months in the TACE group were 100.0%, 81.8% and 50.0%, respectively, and those in TACE+125I group were 100.0%, 93.8% and 65.6%. The mean survival times in the TACE and TACE+125I groups were 19.5 and 22.9 months, respectively. There was a significant difference in the overall survival rate between two groups (P < 0.05). No serious complications were encountered in either group. CONCLUSION Lobaplatin-TACE combined with 125I seed implantation is favorable and safe for treatment of primary HCC.


Oncotarget | 2016

A preoperative mathematic model for computed tomographic guided microwave ablation treatment of hepatic dome tumors.

Fei Gao; Guo Bao Wang; Zhan Wang Xiang; Bin Yang; Jing Bing Xue; Zhi Qiang Mo; Zhi Hui Zhong; Tao Zhang; Fu Jun Zhang; Wei Jun Fan

Purpose This study sought to prospectively evaluate the feasibility and safety of a preoperative mathematic model for computed tomographic(CT) guided microwave(MW) ablation treatment of hepatic dome tumors. Methods This mathematic model was a regular cylinder quantifying appropriate puncture routes from the bottom up. A total of 103 patients with hepatic dome tumors were enrolled and randomly divided into 2 groups based on whether this model was used or not: Group A (using the model; n = 43) versus Group B (not using the model; n = 60). All tumors were treated by CT-guided MW ablation and follow-up contrast CT were reviewed. Results The average number of times for successful puncture, average ablation time, and incidence of right shoulder pain were less in Group A than Group B (1.4 vs. 2.5, P = 0.001; 8.8 vs. 11.1 minutes, P = 0.003; and 4.7% vs. 20%, P = 0.039). The technical success rate was higher in Group A than Group B (97.7% vs. 85.0%, P = 0.032). There were no significant differences between the two groups in primary and secondary technique efficacy rates (97.7% vs. 88.3%, P = 0.081; 90.0% vs. 72.7%, P = 0.314). No major complications occurred in both groups. Conclusion The mathematic model of regular cylinder is feasible and safe for CT-guided MW ablation in treating hepatic dome tumors.


World Journal of Gastroenterology | 2008

Radiofrequency ablation as a treatment for hilar cholangiocarcinoma

Wei Jun Fan; Pei Hong Wu; Liang Zhang; Jin Hua Huang; Fu Jun Zhang; Yang Kui Gu; Ming Zhao; Xiang Long Huang; Chang Yu Guo


Chinese Medical Journal | 2008

CT guided 125iodine seed implantation for portal vein tumor thrombus in primary hepatocellular carcinoma.

Fu Jun Zhang; Chuan Xing Li; De Chao Jiao; Nian Hua Zhang; Pei Hong Wu; Guang Feng Duan; Yue Xia Wu


National Medical Journal of China | 2011

Comparison of safety and efficacy for transcatheter arterial chemoembolization alone and plus radiofrequency ablation in the treatment of single branch portal vein tumor thrombus of hepatocellular carcinoma and their prognosis factors

Ming Zhao; Jian Peng Wang; Wang Li; Zi Lin Huang; Fu Jun Zhang; Wei Jun Fan; Liang Zhang; Xi Shan Li; Chang Chuan Pan; Pei Hong Wu


Chinese journal of cancer | 2005

[Evaluating efficacy of transcatheter arterial chemo-embolization combined with radiofrequency ablation on patients with hepatocellular carcinoma by 18FDG-PET/CT].

Ming Zhao; Pei Hong Wu; Yi Xin Zeng; Fu Jun Zhang; Jin Hua Huang; Wei Jun Fan; Yang Kui Gu; Liang Zhang; Zhi bin Tan; You En Lin


National medical journal of China | 2007

CT guided radioactive 125I seed implantation in treating localized advanced pulmonary carcinoma

Fu Jun Zhang; Chuan Xing Li; Pei Hong Wu; Yue Xia Wu; De Chao Jiao; Jian Liu; Yu Liang Li


National medical journal of China | 2006

Cytokine-induced killer cell fusion to lower recurrence of hepatocellular carcinoma after transcatheter arterial chemoembolization sequentially combined with radiofrequency ablation:a randomized trial

Ming Zhao; Pei Hong Wu; Yi Xin Zeng; Jian Chuan Xia; Fu Jun Zhang; Li Jian Xian; Yu Ping Zhang; Kun Zhou; Wei Jun Fan; Liang Zhang; Fei Gao; Qi Ming Zhou


National medical journal of China | 2006

CT guided radioactive seed 125I implantation in treatment of pancreatic cancer

Fu Jun Zhang; Pei Hong Wu; Ming Zhao; Jin Hua Huang; Wei Jun Fan; Yang Kui Gu; Jian Liu; Liang Zhang; Ming Jian Lu

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Liang Zhang

Sun Yat-sen University

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Wei Jun Fan

Sun Yat-sen University

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Ming Zhao

Sun Yat-sen University

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Yang Kui Gu

Sun Yat-sen University

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Fei Gao

Sun Yat-sen University

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Yue Xia Wu

Sun Yat-sen University

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