Fulya Demirçeken

Hypertrophic osteoarthropathy in a child with biliary atresia.

Hypertrophic osteoarthropathy is a syndrome characterized by clubbing of the digits of the hand/foot, periosteal reaction and arthralgia or arthritis which is usually secondary to cyanotic congenital heart disease and chronic pulmonary infections. This syndrome rarely occurs in association with chronic liver disease in childhood. Here, we report on a child with biliary atresia who developed arthralgia and arthritis during follow‐up and which was diagnosed as hepatic hypertrophic osteoarthropathy. It is emphasized that hypertrophic osteoarthropathy should be considered in the differential diagnosis of arthralgia and arthritis in children with long‐standing chronic liver diseases, especially if finger clubbing is also present.

Serum aminotransferaz aktivite yüksekliğinin asemptomatik müsküler distrofi tanısındaki önemi Olgu Sunumu

Prolonged elevation of serum aminotransferase activity in an asymptomatic child is usually thought to be secondary to liver disease and the patient is referred to a pediatric gastroenterology department However these enzymes also originate from different extrahepatic tissues including skeletal muscle Here two children with persistent elevation of serum aminotransferase levels who were diagnosed as muscular distrophy are presented Patients with persistent and unexplained hypertransaminasemia should be evaluated very carefully and neurologic muscle disease should be considered in the differential diagnosis Key words: serum aminotranferase activity muscular distrophy hypertransaminasemia