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Featured researches published by Fumikazu Akimoto.


Journal of Vascular Surgery | 1991

Eicosapentanoic acid suppresses intimal hyperplasia after expanded polytetrafluoroethylene grafting in rabbits fed a high cholesterol diet

Masaki Ohara; Kensuke Esato; Mikihiko Harada; Yasuhiro Kouchi; Fumikazu Akimoto; Takashi Nakamura; Takafumi Wakamatsu; Nobuya Zempo

The effect of purified eicosapentanoic acid on intimal fibrous hyperplasia in expanded polytetrafluoroethylene grafts was examined in 18 rabbits undergoing infrarenal aorta reconstruction. Six rabbits received commercial rabbit chow (control group), six a regular diet supplemented with 1% cholesterol (cholesterol group), and six the cholesterol diet with 91.1% pure eicosapentanoic acid 500 mg/day (eicosapentanoic acid group). Grafts were harvested 3 months after surgery for histologic examination. The platelet count and serum beta-thromboglobulin and platelet factor 4 concentrations were not significantly different between groups. Serum arachidonic acid level in the cholesterol group was significantly higher than in the control group, and serum eicosapentanoic acid levels in the eicosapentanoic acid group were significantly higher than in the remaining two groups. Intergroup differences in serum 6-keto-prostaglandin F1 alpha and thromboxane B2 concentrations were not significant. Intimal thickness at midgraft was 5.2 +/- 6.2 microns in the control group, 67.6 +/- 46.9 microns in the cholesterol group, and 19.2 +/- 18.4 microns in the eicosapntanoic acid group. intimal thickness in the cholesterol group was greater than in either the control or licosapentanoic acid group (p less than 0.01 and p less than 0.05, respectively). These data suggest that eicosapentanoic acid reduces intimal fibrous proliferation in expanded polytetrafluoroethylene grafting as a result of hypercholesterolemia and that this effect is independent of the platelet count, activated platelet factors, and the prostacyclin/thromboxane A2 ratio.


Surgery Today | 1995

The effect of pancreatopeptidase E (elastase) on anastomotic intimal thickness in two types of vascular prosthesis

Fumikazu Akimoto

To determine the effects of pancreatopeptidase E (elastase) on anastomotic intimal thickness in vascular prostheses, expanded polytetrafluoroethylene (ePTFE) and Dacron grafts were implanted in the infrarenal aortas of 28 adult mongrel dogs, divided into four groups of seven dogs each according to the type of graft used and whether or not elastase was given. Thus, group E received ePTFE grafts without elastase; group D received Dacron grafts without elastase; group E + Ela received ePTFE grafts with concomitant oral elastase, 8 mg/kg per day; and group D + Ela received Dacron grafts with elastase given at the same dosage as in group E + Ela. Each graft was harvested 4 months following surgery for histologic examination. It was clearly observed that elastase suppressed intimal growth at the proximal and distal anastomoses in the ePTFE grafts (P<0.05), but not in the Dacron grafts. Furthermore, when we measured the smooth muscle cell percent extinction (%E) on microspectrophotometry in the intima within 2 mm of the proximal and distal anastomoses, it was found that elastase reduced intimal smooth muscle proliferation at the anastomosis of the ePTFE grafts, but not the Dacron grafts (P<0.05). These data suggest that elastase suppresses intimal growth by inhibiting smooth muscle cell migration and proliferation in the vascular prostheses of low but not of high porosity.


Vascular Surgery | 1988

Transient Division of the Left Renal Vein as Adjunct to Perirenal Aortic Surgery

Kensuke Esato; Hiroaki Takenaka; Kentaro Fujioka; Fumikazu Akimoto; Takashi Nakamura; Masaki Ohhara

In perirenal aortic surgery, a transient division of the left renal vein may be necessary in order to expose the perirenal aorta. Perirenal aortic surgery was performed on 4 patients with infrarenal abdominal aortic aneurysms and 1 pa tient with Leriches syndrome by transection and reanastomosis of the left renal vein. All but 1 of the cases had uneventful postoperative recovery. One of the patients died of septicemia and disseminated intravascular coagulation (DIC) on the fifty-first postoperative day; however, septicemia and DIC were not attrib uted to transient division of the left renal vein. In all of these cases, the renal function stabilized, and no permanent kidney damage relating to the transient division of the left renal vein could be found. Although there have been several reports that ligation and division of the left renal vein are a reasonably safe and acceptable procedure for perirenal aortic surgery, the resuturing of the divided left renal vein is recommended. Although this maneuver is simple, it is impossible to determine the adequacy of collateral venous circulation of the left kidney without extensive dissection.


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1992

CYSTIC ADVENTITIAL DISEASE OF THE POPLITEAL ARTERY

Hiroshi Noda; Kentaro Fujioka; Nobuya Zempo; Takashi Wakamatsu; Masaki Ohara; Takashi Nakamura; Fumikazu Akimoto; Yasuhiro Kochi; Hiroyuki Aikawa; Makihiko Harada; Hiroaki Takenaka; Kensuke Esato


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1990

STEWART-TREVES SYNDROME COMPLICATED BY EMBRYONAL CARCINOMA AS THE THIRD PRIMARY MALIGNANT NEOPLASM

Sumihiko Nawata; Takayuki Kuga; Fumikazu Akimoto; Kensuke Esato; Kenichi Nishida


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1989

COMPOSITE SEQUENTIAL BYPASSES FOR MULUTI-SEGMENTAL ARTERIOSCLEROSIS OBLITERANS

Takashi Nakamura; Kensuke Esato; Hiroaki Takenaka; Kentarou Fujioka; Fumikazu Akimoto; Yasuhiro Kohchi; Toshihiro Nishiyama


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1989

BIOCHEMICAL CHANGES IN THE FEMORAL VENOUS BLOOD DURING RECONSTRUCTIVE AORTIC SURGERY

Yasuhiro Kohchi; Hiroaki Takenaka; Kentaro Fujioka; Fumikazu Akimoto; Takashi Nakamur; Toshihiro Nishiyama; Kensuke Esato


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1988

FALSE ANEURYSM CAUSED BY THE RUPTURE OF A DOUBLE VELOUR DACRON GRAFT

Hiroaki Takenaka; Kensuke Esato; Fumikazu Akimoto; Kentarou Fujioka; Yasuhiro Kouchi; Takashi Nakamura; Toshihiro Nishiyama


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1988

SURGICAL MANAGEMENT OF ARTERIOSCLEROTIC BILATERAL FEMORAL AND RIGHT POPLITEAL ANEURYSMS

Kensuke Esato; Hiroaki Takenaka; Kentaro Fujioka; Fumikazu Akimoto; Takashi Nakamura; Toshihiro Nishiyama


Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1987

SURGICALLY TREATED ISCHEMIC COLITIS -A CASE REPORT-

Fumikazu Akimoto; Osamu Kobayashi; Kiyoshi Shintani; Tomoaki Morita; Toshihiro Kaneyuki

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