Fumio Nagahama
Nihon University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Fumio Nagahama.
Biological Trace Element Research | 2017
Masahiro Lee; Kazumune Arikawa; Fumio Nagahama
Bone remodeling is a vital physiological process of healthy bone tissue in humans. Imbalances in this vital process lead to pathological conditions, including periodontal diseases. In this study, we characterized the effects of micromolar levels of NaF on the proliferation and osteogenic differentiation of MC3T3-E1 osteoblastic cells. NaF significantly enhanced the proliferation, alkaline phosphatase (ALP) activity, and mineralization of MC3T3-E1 cells. Quantitative real-time PCR analysis revealed that the expression of mRNAs encoding runt-related transcription factor 2 (Runx2), Osterix, Osteopontin and Osteocalcin was up-regulated in NaF-treated MC3T3-E1 cells compared with untreated controls. Western blot analysis demonstrated that Runx2 and Osterix were inhibited by Runx2 siRNA but were re-activated by treatment with NaF. Furthermore, in vivo evidence indicated that NaF protects against Porphyromonas gingivalis-induced periodontal inflammation and alveolar bone loss in a P. gingivalis-challenged experimental periodontitis animal model. These data suggest that NaF promotes the osteoblastic differentiation of MC3T3-E1 cells through the Runx2/Osterix pathway and may be effective for the treatment of bone-related disorders.
Dental Materials Journal | 2002
Megumi Nagai; Tohru Hayakawa; Akira Fukatsu; Masafumi Yamamoto; Masahiko Fukumoto; Fumio Nagahama; Hiroyuki Mishima; Masao Yoshinari; Kimiya Nemoto; Takao Kato
International Endodontic Journal | 1998
Moriyasu Wada; Toshihiko Takase; K. Nakanuma; K. Arisue; Fumio Nagahama; Muneyoshi Yamazaki
Archives of Microbiology | 2014
Osamu Tsuzukibashi; Masanori Saito; Taira Kobayashi; Koji Umezawa; Fumio Nagahama; Takachika Hiroi; Masatomo Hirasawa; Kazuko Takada
The Journal of Nihon University School of Dentistry | 1996
Toshihiko Takase; Moriyasu Wada; Fumio Nagahama; Muneyoshi Yamazaki
International Journal of Oral-Medical Sciences | 2014
Hiroya Gotouda; Kazutaka Kasai; Seiko Osawa; Yasuhiro Okamoto; Takemi Goseki; Toshikazu Kuroki; Nobuyuki Kikuchi; Hideki Makimura; Fumio Nagahama; Yasuhiko Kawai; Misao Kawara; Takanori Ito; Moriyasu Wada; Ikuo Nasu; Koh Shibutani; Masaharu Makimura
International Journal of Oral-Medical Sciences | 2015
Toshikazu Uchiyama; Hiroyuki Tanaka; Kazumune Arikawa; Chieko Taguchi; Suguru Kimoto; Megumi Fuse; Yoko Yokota; Nobuyuki Kikuchi; Chikako Nishitani; Hideki Makimura; Fumio Nagahama; Akira Fukatsu; Yoshiharu Kono; Masahiko Fukumoto; Moriyasu Wada
Journal of Oral Biosciences | 2013
Tamami Okada; Kou Fujita; Hideaki Suzuki; Osamu Tsuzukibashi; Koji Umezawa; Fumio Nagahama; Takuji Ikemi; Kazuko Takada
International Journal of Oral-Medical Sciences | 2013
Osamu Tsuzukibashi; Satoshi Uchibori; Noriko Shinozaki-Kuwahara; Masanori Saito; Fumio Nagahama; Taira Kobayashi; Masahiko Fukumoto
International Journal of Oral-Medical Sciences | 2013
Fumio Nagahama; Osamu Tsuzukibashi; Satoshi Uchibori; Masahiko Fukumoto