Funda Canaz

Malignant myoepithelioma of the palate: a case report with review of the clinicopathological characteristics.

A malignant myoepithelioma is one of the rarest salivary gland neoplasms which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma. The parotid gland is the most common primary site and the palate the most common intra-oral site of occurrence. Herein is present a case of a malignant myoepithelioma arising in the hard palate of a 79-year-old woman. The lesion had been examined by biopsy at another hospital, and diagnosed as a poorly differentiated squamous cell carcinoma. The patient underwent a wide local tumor resection. Examination of the resection specimen showed the characteristic histopathological and immunohistochemical features of a malignant myoepithelioma. Five months after the operation, the patient was well without evidence of recurrence or metastasis.

Survival of diced and block cartilage grafts in combination with injectable calcium hydroxylapatite

Dorsal nasal irregularities after trauma, and various procedures such as excessive nasal hump resection, are major problems for patients who have undergone rhinoplasty. Many grafts have been described for the correction of dorsal nasal irregularities. In this study, we used an injectable implant, in combination with diced or block cartilage grafts, to test the efficacy of injectable calcium hydroxylapatite on the survival of diced or block cartilage grafts.

Superimposed segmental manifestation of juvenile amyopathic dermatomyositis in a 9-year-old boy

Dermatomyositis is a well-known autoimmune disorder. On the other hand, juvenile amyopathic dermatomyositis (JADM) occurs rather rarely. Here, we report an unusual case in a 9-year-old Turkish boy showing a unilateral linear inflammatory skin lesion that was followed, after 16 months, by the appearance of bilateral disseminated features JADM.

Larinksin az görülen skuamöz hücreli karsinom varyantları: tek merkeze ait 7 yıllık deneyim

Larinksin malign epitelyal tum o rleri arasinda skuam o z hucreli karsinom en sik g o rulendir. Daha c ok erkeklerde, 6. ve 7. dekadlarda g o rulur. Son yillarda tutun ve alkol kullaniminin artmasi nedeniyle kadinlarda da insidansinin yukseldigi bildirilmektedir. Skuam o z hucreli karsinom supraglottik ve glottik b o lgede daha sik g o rulur. Dunya Saglik Orgutu, skuam o z hucreli karsinomun farkli alt tiplerini tanimlamistir. Bu varyantlardan bazilari konvansiyonel skuam o z hucreli karsinoma g o re daha iyi, bazilari ise daha k o tu prognozludur. Calismamizda skuam o z hucreli karsinomun az g o rulen varyantlari sunulmaktadir. Gerec ve Yontem: … Tip Fakultesi Patoloji Anabilim Dali’nda son 7 yillik d o nemde tum larinks biyopsileri taranmistir. Skuam o z hucreli karsinom varyantlari seklinde tani alan hastalar belirlenmis, olgularin histopatolojik ve klinik o zellikleri derlenmistir. Bulgular: Yedi yillik d o nemde larinks biyopsisi yapilan 1148 olgu bulunmaktadir. Bu olgulardan 460’i skuam o z hucreli karsinom tanisi almistir. Bunlardan 31’i nadir g o rulen skuam o z hucreli karsinom varyantidir. Bunlar arasinda 3 verruk o z karsinom, 6 bazaloid, 11 papiller, 4 ig si h ucreli, 6 akantolitik varyant skuam o z hucreli karsinom olgusu mevcuttur. Bir olgu ise adenoskuam o z karsinom tanilidir. Verruk o z karsinom olgularinda tum o r vokal kord yerlesimlidir. Bazaloid varyant ise olgularin tumunde supraglottik b o lgede saptanmistir. Diger varyantlarda glottik ve supraglottik b o lge degisen oranlarda tutulmaktadir. Olgularin sadece birinde infraglottik tum o r mevcuttur. Bu olgu akantolitik varyant skuam o z hucreli karsinom olarak degerlendirilmistir. Sonu c : Larinksin skuam o z hucreli karsinomunun az g o rulen varyantlarinin biyolojik davranislari farkliliklar g o stermektedir. Bu tum o rler multidisipliner yaklasim ile efektif sekilde tedavi edilebilir. Alt tiplerin taninmasi ve tariflenmesi uygun tedavi yaklasiminin belirlenebilmesi i c in gereklidir.

Nephrogenic adenoma of the urinary tract: A 6-year single center experience

BACKGROUND Nephrogenic adenoma is an uncommon benign lesion that occurs at several sites in urinary tract, from the renal pelvis to urethra, with the highest frequency in urinary bladder. Nephrogenic adenoma displays a broad spectrum of architectural and cytological features. Hence, recognition of its characteristic histopathological features is needed to distinguish this lesion from its mimickers. MATERIALS AND METHODS A retrospective series of 21 cases of nephrogenic adenoma in 18 patients, which were diagnosed in our department between 2010 and 2016, were analyzed. All histological slides were reviewed by two pathologists and the diagnosis of each case was confirmed. Immunohistochemistry was performed for PAX-8 in all cases. CK7, PAX-2, PSA, p53, p63, GATA-3 and α-methylacyl-CoA racemase (AMACR) were applied in problematic cases. RESULTS The most common location of the lesion was urinary bladder (14 patients) followed by renal pelvis (2 patients), ureter (1 patient) and urethra (1 patient). A history of urothelial carcinoma and repeated TUR procedures were observed in 12 patients. There were 2 pediatric patients aged 3 years. Both of them had undergone previous urosurgery because of megaureter in one and bladder exstrophy in the other. Other clinical antecedents included bladder diverticulum (1 patient), cystitis (1 patient) and nephrolithiasis (1 patient). Recurrence of lesion was seen in two patients (once in one case and twice in the other one). The median time to disease recurrence in these patients was 11 months (range, 2-20 months). Histologically, the lesions exhibited various morphological findings, with mixed (15 cases, 71.4%), pure tubular (3 cases, 14.3%), pure papillary (2 cases, 9.5%) and pure flat (1 case, 4.8%) growth patterns. Of the 15 cases with mixed patterns, 8 cases were tubulocystic and flat, 3 cases were tubular and flat, 2 cases were tubular, papillary and flat, 1 case was tubulocystic, papillary and flat, and 1 case was tubular and papillary. Flat pattern was observed in 15 cases (71.4%). It was seen in association with other patterns in 14 cases (mixed morphology) and purely in 1 case. Our findings suggested that the flat pattern is a frequent finding in nephrogenic adenomas. Notably one case in this series showed superficial extension into bladder muscularis propria. CONCLUSIONS Histologically nephrogenic adenoma may simulate a variety of malignancies. Awareness of characteristic morphologic features of nephrogenic adenoma is needed to diagnose this lesion correctly.

Is there a relation between the changes in circulating lymphocyte counts due to neoadjuvant chemoradiotherapy and intratumoral lymphocytic response and tumor regression grade in locally advanced rectal cancers

There are controversies about the relation between the peripheral lymphocyte levels and response to neoadjuvant therapy. While some authors have reported that a positive correlation between peripheral lymphocyte levels and tumor response, others have suggested the opposite. In the present study, we aimed to investigate the possible relations between the changes in circulating lymphocyte counts due to neoadjuvant chemoradiotherapy (CRT) and intratumoral lymphocytic response (ILR) and tumor regression grade (TRG) in locally advanced rectal cancers. Lymphocyte levels before, during and after CRT as well as before surgery and pathologic findings including ILRs and TRGs were recorded. Lymphocyte levels before CRT were accepted as absolute values. After the changes in the lymphocyte levels during and after CRT and before the surgery were recorded as ratios to the absolute values, the relation between the changes in lymphocyte levels, ILR and TRG were studied by using Pearson and Spearman correlation tests. There was a positive correlation between changes in peripheral lymphocytic levels after neoadjuvant CRT and ILRs. However, there were no other correlations between changes in lymphocytic levels and TRGs and ILRs. The changes in the peripheral lymphocyte counts after CRT may be predictive for ILR. Further studies may provide more information about the relation between peripheral lymphocytes and TILs and tumor response to neoadjuvant CRT.

Efficacy of Platelet-Rich Plasma on Fat Grafts in the Repair of Tympanic Membrane Perforations: An Experimental Study

OBJECTIVE We investigated the use of autologous platelet-rich plasma (PRP) to improve the success rate of fat graft myringoplasty in perforated tympanic membranes of rats. MATERIALS AND METHODS A total of 20 healthy Wistar albino female rats were divided into two groups. In Group 1, the left tympanic membranes were perforated and grafted with a fat graft that was harvested from the inguinal region. In Group 2, the left tympanic membranes were perforated, and a fat graft was also harvested from the inguinal region. Then, the fat was soaked in 0.5 mL PRP and grafted at the perforation. After the procedure, the rats were examined, and the graft situation was assessed at 3, 5, 7, 10, and 14 days. All of the rats were sacrificed 21 days after perforation, and a histopathological examination was made. RESULTS We compared fat graft histopathological and otomicroscopic findings between the groups. While we did not observe graft rejections in Group 2, we saw 1 case of graft rejection in Group 1. In the histopathological examination, PRP prevents fat graft resorption by the terms of the adipocyte area, granulation tissue area, and vacuolization area. CONCLUSION This study demonstrated the efficacy of fat grafts prepared with PRP on rat tympanic membranes. The fat graft with PRP did not statistically improve the success rate compared to the graft without PRP. Histopatologic findings of the study showed that PRP prevents fat graft resorption. Further studies are needed to further examine the advantages of the graft with PRP.

Bilateral painless testicular mass, acute uveitis and annular cutaneous lesions: an unusual presentation of sarcoidosis and literature review

Ahead of Print article withdrawn by publisher.

Adrenocortical Oncocytic Carcinoma: A Case Report and Review of the Histopathologic Diagnostic Criteria.

Abstract Oncocytic tumors are rare in the adrenal gland. The histopathological diagnosis of adrenocortical carcinoma is difficult due to the lack of precise diagnostic criteria for malignancy. A 44-year-old man was admitted to our hospital with left flank pain. Radiologically an adrenal mass was detected. After the excision and histopathologic evaluation of the mass, a diagnosis of adrenocortical oncocytic carcinoma was made. At least one of the features of more than 5 mitoses in 50 high power fields, atypical mitotic figures or venous invasion is required for the diagnosis of malignancy in adrenocortical tumors. It has been suggested that tumors that have more than one of the minor criteria of large size (>10 cm or >200 gr), necrosis, capsular or sinusoidal invasion, should be evaluated as having uncertain malignant potential.