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Dive into the research topics where Futami Kosaka is active.

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Featured researches published by Futami Kosaka.


Intensive Care Medicine | 1989

Effect of pressure support ventilation on breathing patterns and respiratory work

Hiroaki Tokioka; S. Saito; Futami Kosaka

AbstractWe assessed the effect of pressure support ventilation (PSV) on breathing patterns and the work of breathing in 10 postoperative patients. Minute ventilation (


Neuroscience Letters | 1991

Bacterial endotoxin-induced expression of metallothionein genes in rat brain, as revealed by in situ hybridization

Yoshitaro Itano; Sumihare Noji; Eiki Koyama; Shigehiko Taniguchi; Naoyuki Taga; Toru Takahashi; Katsuhiko Ono; Futami Kosaka


Acta Neuropathologica | 1990

Histological changes of neuronal damage in vegetative dogs induced by 18 minutes of complete global brain ischemia: two-phase damage of Purkinje cells and hippocampal CA1 pyramidal cells

M. Sato; H. Hashimoto; Futami Kosaka

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Toxicology and Applied Pharmacology | 1989

Elevation in metallothionein messenger RNA in rat tissues after exposure to X-irradiation

Noriyuki Shiraishi; Hidehiro Hayashi; Yoshio Hiraki; Kaname Aono; Yoshitaro Itano; Futami Kosaka; Sumihare Noji; Shigehiko Taniguchi


Intensive Care Medicine | 1989

Comparison of pressure support ventilation and assist control ventilation in patients with acute respiratory failure.

Hiroaki Tokioka; S. Saito; Futami Kosaka

E) increased by 8% with 5 cm H2O PSV and 10% with 10 cm H2O PSV compared to 0 cm H2O PSV. The increase in


Intensive Care Medicine | 1985

The acute effects of prostaglandin E1 on the pulmonary circulation and oxygen delivery in patients with the adult respiratory distress syndrome.

Hiroaki Tokioka; O. Kobayashi; Y. Ohta; T. Wakabayashi; Futami Kosaka


Critical Care Medicine | 1990

Efficacy of flow-by during continuous positive airway pressure ventilation

Seiko Saito; Hiroaki Tokioka; Futami Kosaka

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Acta Anaesthesiologica Scandinavica | 1992

Effectiveness of pressure support ventilation for mechanical ventilatory support in patients with status asthmaticus

Hiroaki Tokioka; S. Saito; Toru Takahashi; Minoru Kinjo; Shinsei Saeki; Futami Kosaka; Masahisa Hirakawa


Naunyn-schmiedebergs Archives of Pharmacology | 1987

Effects of halothane, enflurane and pentobarbital on brain histamine dynamics in mice

Miwa Baba; Masahiro Nishibori; Ryozo Oishi; Kiyomi Saeki; Futami Kosaka

E was achieved by increased mean inspiratory flow (24% with 5 cm H2O PSV and 67% with 10 cm H2O PSV) and a decrease in duty cycle (13% with 5 cm H2O PSV and 39% with 10 cm H2O PSV). The decrease in duty cycle along with a decrease in respiratory frequency allowed a greater expiratory time including a rest period for the respiratory muscles, which might minimize the risk of muscle fatigue. Furthermore, the inspiratory work added by the ventilator was near zero with 5 cm H2O PSV and 10 cm H2O PSV. Oxygen consumption also decreased significantly with 5 cm H2O PSV. We conclude that PSV improves the breathing patterns and minimizes the work of breathing spontaneously via a ventilator.


Experientia. Supplementum | 1987

Metallothionein and zinc metabolism in endotoxin shock rats.

Shinya Abe; Masaki Matsumi; Mitsunori Tsukioki; Shunichi Mizukawa; Tooru Takahashi; Yoshio Iijima; Yoshitaro Itano; Futami Kosaka

In order to clarify acute-phase response in brain, we investigated induction of metallothionein (MT) genes by administrating an endotoxin (lipopolysaccharide) in rat intraperitoneum. We performed in situ hybridization on the serial brain sections to identify the cells expressing the MT genes in acute-phase. After endotoxin administration, transcripts of MT genes were detected in the arachnoideal, ependymal cells and glial cells around the Purkinje cells of the cerebellum, while no significant induction of the MT genes by zinc ion was observed in brain. These results suggest that the acute-phase response occurs specifically in at least these 3 non-neuronal cells.

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