Futara Ono

The Reaction of Phenolic Compounds with Isoprenoids. Part VII.1) ortho-Prenylation of Phenol in the Presence of Alkali-Metal Catalysts

Abstract ortho-Prenylphenols and its derivatives occur frequently in plants and microorganism,2) and have been assumed to be essential intermediates in the biosynthesis of some natural products. ortho-Prenylphenols have been synthesized by the Friedel-Crafts reaction of prenyl alcohols or prenyl halides with phenols,3)-6) or by direct alkylation of phenols with polyprenyl halides in the alkaline media.7) These reactions had no

Synthesis of Grifolin and its Homologues1)

Abstract In regard to the synthesis of grifolin [I] which is an antibiotic fungal metabolite,2) the condensation of orcinol with farnesol and farnesyl bromide by toluene-p-sulphonic acid,3) oxalic acid,4) and others5,6) have been reported recently.